Site-specific modification by functionality-transfer oligonucleotide with the photo-inducible reactivity.

Kazumitsu Onizuka; Yosuke Taniguchi; Takamasa Nishioka; Shigeki Sasaki

Site-specific modification by functionality-transfer oligonucleotide with the photo-inducible reactivity.

Kazumitsu Onizuka, Yosuke Taniguchi, Takamasa Nishioka, Shigeki Sasaki

Chemo-Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Previously, we reported that S-vinyl thioguanosine analogs exhibited the efficient functionality-transfer reaction with selectivity toward cytidine. This technique was applied to the inhibition and the labelling of DNA or RNA. In this study, we aimed at developing functionality-transfer oligonucleotide with the photo-inducible reactivity. This photo-induced transfer reaction proceeded only to d(m)C but not to dC and dT at the target site of the complementary ODN.

Original language	English
Pages (from-to)	367-368
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	52
Publication status	Published - 2008

All Science Journal Classification (ASJC) codes

Medicine(all)

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title = "Site-specific modification by functionality-transfer oligonucleotide with the photo-inducible reactivity.",

abstract = "Previously, we reported that S-vinyl thioguanosine analogs exhibited the efficient functionality-transfer reaction with selectivity toward cytidine. This technique was applied to the inhibition and the labelling of DNA or RNA. In this study, we aimed at developing functionality-transfer oligonucleotide with the photo-inducible reactivity. This photo-induced transfer reaction proceeded only to d(m)C but not to dC and dT at the target site of the complementary ODN.",

author = "Kazumitsu Onizuka and Yosuke Taniguchi and Takamasa Nishioka and Shigeki Sasaki",

year = "2008",

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AU - Taniguchi, Yosuke

AU - Nishioka, Takamasa

AU - Sasaki, Shigeki

PY - 2008

Y1 - 2008

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AB - Previously, we reported that S-vinyl thioguanosine analogs exhibited the efficient functionality-transfer reaction with selectivity toward cytidine. This technique was applied to the inhibition and the labelling of DNA or RNA. In this study, we aimed at developing functionality-transfer oligonucleotide with the photo-inducible reactivity. This photo-induced transfer reaction proceeded only to d(m)C but not to dC and dT at the target site of the complementary ODN.

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