Site-specific modification by functionality-transfer oligonucleotide with the photo-inducible reactivity.

Kazumitsu Onizuka, Yosuke Taniguchi, Takamasa Nishioka, Shigeki Sasaki

Research output: Contribution to journalArticle

Abstract

Previously, we reported that S-vinyl thioguanosine analogs exhibited the efficient functionality-transfer reaction with selectivity toward cytidine. This technique was applied to the inhibition and the labelling of DNA or RNA. In this study, we aimed at developing functionality-transfer oligonucleotide with the photo-inducible reactivity. This photo-induced transfer reaction proceeded only to d(m)C but not to dC and dT at the target site of the complementary ODN.

Original languageEnglish
Pages (from-to)367-368
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number52
Publication statusPublished - 2008

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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