Site-specific modification of RNA by functionality-transfer ODN probes.

Kazumitsu Onizuka, Yosuke Taniguchi, Takamasa Nishioka, Shigeki Sasaki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Efficient methods for the modification of RNA molecules have been expected as innovative biological tools and therapeutic methods. In this study, the development of a general method for site-specific RNA modification by the functionality-transfer ODN probes has been investigated. Site-specific and cytosine-selective RNA modifications were achieved by the functionality-transfer reaction. It was shown that the base and site-selectivity were due to the close proximity of the reactants in the DNA-RNA duplexes.

Original languageEnglish
Pages (from-to)67-68
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number53
Publication statusPublished - Jan 1 2009

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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