Skein-like inclusions in the neostriatum from a case of amyotrophic lateral sclerosis with dementia

Toshiro Kawashima, Hitoshi Kikuchi, Masashi Takita, Katsumi Doh-ura, Koji Ogomori, Mariko Oda, Toru Iwaki

Research output: Contribution to journalArticle

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Abstract

Skeins or skein-like inclusions (SLIs) in motor neurons detected by ubiquitin immunohistochemistry are a characteristic finding of amyotrophic lateral sclerosis (ALS). Here we report ubiquitinated SLIs in the putamen and caudate nucleus from a case of ALS with dementia. A 48-year-old Japanese man developed apathy and amimia. Mental and neurological examinations revealed severe character change, muscle atrophy and fasciculation of the distal upper extremities and the tongue, and an exaggeration of the deep tendon reflex. He subsequently showed dysphagia and dysarthria. He died at the age of 51 years, after a total clinical course of about 2.5 years. By immunohistochemistry, ubiquitin-immunoreactive intraneuronal inclusions were observed in the spinal anterior horn cells, the frontal, temporal and entorhinal cortices, dentate fascia of the hippocampus and the amygdala. In addition, ubiquitinated inclusions were also seen in the putamen and caudate nucleus, which appeared as aggregates of thread-like structures similar to SLIs in the spinal anterior horn neurons. They were not seen on hematoxylin-eosin staining, and they also did not show any argentophilia nor did they react with other antibodies, including antibody against tau protein. To our knowledge, this is the first report of the presence of SLIs in non-motor neurons. Our results thus support the notion that ALS is a multisystem disease, and not simply a disease of the motor neurons.

Original languageEnglish
Pages (from-to)541-545
Number of pages5
JournalActa neuropathologica
Volume96
Issue number5
DOIs
Publication statusPublished - Nov 1 1998

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Neostriatum
Amyotrophic Lateral Sclerosis
Anterior Horn Cells
Caudate Nucleus
Putamen
Ubiquitin
Immunohistochemistry
Fasciculation
Apathy
tau Proteins
Stretch Reflex
Dysarthria
Motor Neuron Disease
Entorhinal Cortex
Muscular Atrophy
Antibodies
Dentate Gyrus
Neurologic Examination
Frontal Lobe
Motor Neurons

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Skein-like inclusions in the neostriatum from a case of amyotrophic lateral sclerosis with dementia. / Kawashima, Toshiro; Kikuchi, Hitoshi; Takita, Masashi; Doh-ura, Katsumi; Ogomori, Koji; Oda, Mariko; Iwaki, Toru.

In: Acta neuropathologica, Vol. 96, No. 5, 01.11.1998, p. 541-545.

Research output: Contribution to journalArticle

Kawashima, Toshiro ; Kikuchi, Hitoshi ; Takita, Masashi ; Doh-ura, Katsumi ; Ogomori, Koji ; Oda, Mariko ; Iwaki, Toru. / Skein-like inclusions in the neostriatum from a case of amyotrophic lateral sclerosis with dementia. In: Acta neuropathologica. 1998 ; Vol. 96, No. 5. pp. 541-545.
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