Skeletal muscle mass predicts the prognosis of patients with intrahepatic cholangiocarcinoma

Kyohei Yugawa, Shinji Itoh, Takeshi Kurihara, Shohei Yoshiya, Yohei Mano, Kazuki Takeishi, Noboru Harada, Toru Ikegami, Yuji Soejima, Masaki Mori, Tomoharu Yoshizumi

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Abstract

Background: We studied the prognostic impact of sarcopenia after hepatic resection for intrahepatic cholangiocarcinoma (ICC). Methods: Sixty-one patients who underwent surgery for ICC during 2000–2017 were analyzed retrospectively. Psoas muscle areas were measured on CT scans at the third lumbar vertebra. Areas less than the sex-specific median were deemed low skeletal muscle masses (SMMs). Results: Low-SMM patients were significantly more often older (p = 0.002) than high-SMM patients, had lower serum albumin (p = 0.004), higher serum C-reactive protein (CRP) (p = 0.002), and higher carbohydrate antigen 19-9 (p < 0.001). Five-year overall survival rates were 72.5% and 17.6% and 5-year recurrence-free survival rates were 58.6% and 21.1%, respectively, in high- and low-SMM patients. Multivariable analysis revealed that low SMM predicted unfavorable prognoses. SMM was associated with immune nutritional status (e.g., prognostic nutritional index, Glasgow prognostic score, CRP/albumin ratio). Conclusion: Low SMM was related to worse surgical outcomes in patients with ICC following hepatic resection.

Original languageEnglish
Pages (from-to)952-958
Number of pages7
JournalAmerican Journal of Surgery
Volume218
Issue number5
DOIs
Publication statusPublished - Nov 2019

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Cholangiocarcinoma
Skeletal Muscle
C-Reactive Protein
Survival Rate
Psoas Muscles
Sarcopenia
Lumbar Vertebrae
Nutrition Assessment
Liver
Nutritional Status
Serum Albumin
Blood Proteins
Albumins
Carbohydrates
Antigens
Recurrence

All Science Journal Classification (ASJC) codes

  • Surgery

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Skeletal muscle mass predicts the prognosis of patients with intrahepatic cholangiocarcinoma. / Yugawa, Kyohei; Itoh, Shinji; Kurihara, Takeshi; Yoshiya, Shohei; Mano, Yohei; Takeishi, Kazuki; Harada, Noboru; Ikegami, Toru; Soejima, Yuji; Mori, Masaki; Yoshizumi, Tomoharu.

In: American Journal of Surgery, Vol. 218, No. 5, 11.2019, p. 952-958.

Research output: Contribution to journalArticle

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abstract = "Background: We studied the prognostic impact of sarcopenia after hepatic resection for intrahepatic cholangiocarcinoma (ICC). Methods: Sixty-one patients who underwent surgery for ICC during 2000–2017 were analyzed retrospectively. Psoas muscle areas were measured on CT scans at the third lumbar vertebra. Areas less than the sex-specific median were deemed low skeletal muscle masses (SMMs). Results: Low-SMM patients were significantly more often older (p = 0.002) than high-SMM patients, had lower serum albumin (p = 0.004), higher serum C-reactive protein (CRP) (p = 0.002), and higher carbohydrate antigen 19-9 (p < 0.001). Five-year overall survival rates were 72.5{\%} and 17.6{\%} and 5-year recurrence-free survival rates were 58.6{\%} and 21.1{\%}, respectively, in high- and low-SMM patients. Multivariable analysis revealed that low SMM predicted unfavorable prognoses. SMM was associated with immune nutritional status (e.g., prognostic nutritional index, Glasgow prognostic score, CRP/albumin ratio). Conclusion: Low SMM was related to worse surgical outcomes in patients with ICC following hepatic resection.",
author = "Kyohei Yugawa and Shinji Itoh and Takeshi Kurihara and Shohei Yoshiya and Yohei Mano and Kazuki Takeishi and Noboru Harada and Toru Ikegami and Yuji Soejima and Masaki Mori and Tomoharu Yoshizumi",
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T1 - Skeletal muscle mass predicts the prognosis of patients with intrahepatic cholangiocarcinoma

AU - Yugawa, Kyohei

AU - Itoh, Shinji

AU - Kurihara, Takeshi

AU - Yoshiya, Shohei

AU - Mano, Yohei

AU - Takeishi, Kazuki

AU - Harada, Noboru

AU - Ikegami, Toru

AU - Soejima, Yuji

AU - Mori, Masaki

AU - Yoshizumi, Tomoharu

PY - 2019/11

Y1 - 2019/11

N2 - Background: We studied the prognostic impact of sarcopenia after hepatic resection for intrahepatic cholangiocarcinoma (ICC). Methods: Sixty-one patients who underwent surgery for ICC during 2000–2017 were analyzed retrospectively. Psoas muscle areas were measured on CT scans at the third lumbar vertebra. Areas less than the sex-specific median were deemed low skeletal muscle masses (SMMs). Results: Low-SMM patients were significantly more often older (p = 0.002) than high-SMM patients, had lower serum albumin (p = 0.004), higher serum C-reactive protein (CRP) (p = 0.002), and higher carbohydrate antigen 19-9 (p < 0.001). Five-year overall survival rates were 72.5% and 17.6% and 5-year recurrence-free survival rates were 58.6% and 21.1%, respectively, in high- and low-SMM patients. Multivariable analysis revealed that low SMM predicted unfavorable prognoses. SMM was associated with immune nutritional status (e.g., prognostic nutritional index, Glasgow prognostic score, CRP/albumin ratio). Conclusion: Low SMM was related to worse surgical outcomes in patients with ICC following hepatic resection.

AB - Background: We studied the prognostic impact of sarcopenia after hepatic resection for intrahepatic cholangiocarcinoma (ICC). Methods: Sixty-one patients who underwent surgery for ICC during 2000–2017 were analyzed retrospectively. Psoas muscle areas were measured on CT scans at the third lumbar vertebra. Areas less than the sex-specific median were deemed low skeletal muscle masses (SMMs). Results: Low-SMM patients were significantly more often older (p = 0.002) than high-SMM patients, had lower serum albumin (p = 0.004), higher serum C-reactive protein (CRP) (p = 0.002), and higher carbohydrate antigen 19-9 (p < 0.001). Five-year overall survival rates were 72.5% and 17.6% and 5-year recurrence-free survival rates were 58.6% and 21.1%, respectively, in high- and low-SMM patients. Multivariable analysis revealed that low SMM predicted unfavorable prognoses. SMM was associated with immune nutritional status (e.g., prognostic nutritional index, Glasgow prognostic score, CRP/albumin ratio). Conclusion: Low SMM was related to worse surgical outcomes in patients with ICC following hepatic resection.

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