Sleep disorders among Yusho patients highly intoxicated with dioxin-related compounds: A 140-case series

Hideaki Kondo, Keiko Tanio, Yuki Nagaura, Mako Nagayoshi, Chikage Mitoma, Masutaka Furue, Takahiro Maeda

Research output: Contribution to journalArticle

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Abstract

Purpose: Patients with Yusho, a condition caused by exposure to dioxins and dioxin-like compounds, have diverse mental and physical complaints. However, the relationship between dioxins and sleep disorders has not yet been examined. This cross-sectional study was designed to investigate problems associated with sleep among patients with Yusho. Methods: A total of 140 participants (52.9% men, average age: 67.1 ± 12.2 years) were examined using questionnaires and medical interviews by an expert on sleep medicine. Demographic and clinical characteristics, including blood concentrations of 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), which is the major cause of Yusho, were obtained from the results of recent surveys conducted by the Yusho Study Group. Results: Moderate to severe symptoms of insomnia were present in 51.8% of the patients. The median Pittsburgh Sleep Quality Index global score (PSQI GS) was 8 (interquartile range: 5–11). The prevalence of restless legs syndrome/Willis–Ekbom disease (RLS/WED) was 30.7%; 24.3% of patients had severe RLS/WED (distressing symptoms with a frequency ≥ 1day per week). A higher blood concentration of 2,3,4,7,8-PeCDF (≥72.27 pg/g lipid) and severe RLS/WED were associated with higher odds of a PSQI GS ≥8, after adjusting for covariates (odds ratio [95% confidence interval]: 4.84 [1.10–21.25] and 4.15 [1.53–11.28], respectively). Conclusions: Symptoms of insomnia were frequent, and the prevalence of RLS/WED was high in patients with Yusho. In addition to the presence of RLS/WED, a higher blood concentration of 2,3,4,7,8-PeCDF was associated with lower subjective sleep quality.

Original languageEnglish
Pages (from-to)261-268
Number of pages8
JournalEnvironmental Research
Volume166
DOIs
Publication statusPublished - Oct 1 2018

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Restless Legs Syndrome
Dioxins
sleep
dioxin
Sleep
Sleep Initiation and Maintenance Disorders
Blood
blood
confidence interval
Cross-Sectional Studies
Odds Ratio
Medicine
Demography
Sleep Wake Disorders
Confidence Intervals
Interviews
Lipids
lipid
2,3,4,7,8-pentachlorodibenzofuran

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Environmental Science(all)

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Sleep disorders among Yusho patients highly intoxicated with dioxin-related compounds : A 140-case series. / Kondo, Hideaki; Tanio, Keiko; Nagaura, Yuki; Nagayoshi, Mako; Mitoma, Chikage; Furue, Masutaka; Maeda, Takahiro.

In: Environmental Research, Vol. 166, 01.10.2018, p. 261-268.

Research output: Contribution to journalArticle

Kondo, Hideaki ; Tanio, Keiko ; Nagaura, Yuki ; Nagayoshi, Mako ; Mitoma, Chikage ; Furue, Masutaka ; Maeda, Takahiro. / Sleep disorders among Yusho patients highly intoxicated with dioxin-related compounds : A 140-case series. In: Environmental Research. 2018 ; Vol. 166. pp. 261-268.
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abstract = "Purpose: Patients with Yusho, a condition caused by exposure to dioxins and dioxin-like compounds, have diverse mental and physical complaints. However, the relationship between dioxins and sleep disorders has not yet been examined. This cross-sectional study was designed to investigate problems associated with sleep among patients with Yusho. Methods: A total of 140 participants (52.9{\%} men, average age: 67.1 ± 12.2 years) were examined using questionnaires and medical interviews by an expert on sleep medicine. Demographic and clinical characteristics, including blood concentrations of 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), which is the major cause of Yusho, were obtained from the results of recent surveys conducted by the Yusho Study Group. Results: Moderate to severe symptoms of insomnia were present in 51.8{\%} of the patients. The median Pittsburgh Sleep Quality Index global score (PSQI GS) was 8 (interquartile range: 5–11). The prevalence of restless legs syndrome/Willis–Ekbom disease (RLS/WED) was 30.7{\%}; 24.3{\%} of patients had severe RLS/WED (distressing symptoms with a frequency ≥ 1day per week). A higher blood concentration of 2,3,4,7,8-PeCDF (≥72.27 pg/g lipid) and severe RLS/WED were associated with higher odds of a PSQI GS ≥8, after adjusting for covariates (odds ratio [95{\%} confidence interval]: 4.84 [1.10–21.25] and 4.15 [1.53–11.28], respectively). Conclusions: Symptoms of insomnia were frequent, and the prevalence of RLS/WED was high in patients with Yusho. In addition to the presence of RLS/WED, a higher blood concentration of 2,3,4,7,8-PeCDF was associated with lower subjective sleep quality.",
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AU - Kondo, Hideaki

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