Abstract
We report a case of O'Sullivan-McLeod syndrome in a 59-year-old man, who had experienced slowly progressive weakening of both hands since he was 20 years of age. Mild hyperIgEemia and eosinophilia were present. Nerve conduction studies revealed reduced F wave-evoked frequencies for the median and ulnar nerves. Intravenous immunoglobulin (IVIG) at a dose of 400 mg/kg/day was given for 5 days. After IVIG, the muscle weakness of the distal upper extremities improved together with increased F wave-evoked frequencies. These effects lasted for a few months. These observations suggest that immune-mediated neural damage partially contributes to O'Sullivan-McLeod syndrome.
| Original language | English |
|---|---|
| Pages (from-to) | 515-518 |
| Number of pages | 4 |
| Journal | Internal Medicine |
| Volume | 46 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Apr 17 2007 |
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All Science Journal Classification (ASJC) codes
- Internal Medicine
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Slowly progressive distal muscular atrophy of the bilateral upper limbs (O'Sullivan-McLeod syndrome) partially alleviated by intravenous immunoglobulin therapy. / Kawano, Yuji; Nagara, Yuko; Murai, Hiroyuki; Kikuchi, Hitoshi; Ohyagi, Yasumasa; Kira, Jun-Ichi.
In: Internal Medicine, Vol. 46, No. 8, 17.04.2007, p. 515-518.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Slowly progressive distal muscular atrophy of the bilateral upper limbs (O'Sullivan-McLeod syndrome) partially alleviated by intravenous immunoglobulin therapy
AU - Kawano, Yuji
AU - Nagara, Yuko
AU - Murai, Hiroyuki
AU - Kikuchi, Hitoshi
AU - Ohyagi, Yasumasa
AU - Kira, Jun-Ichi
PY - 2007/4/17
Y1 - 2007/4/17
N2 - We report a case of O'Sullivan-McLeod syndrome in a 59-year-old man, who had experienced slowly progressive weakening of both hands since he was 20 years of age. Mild hyperIgEemia and eosinophilia were present. Nerve conduction studies revealed reduced F wave-evoked frequencies for the median and ulnar nerves. Intravenous immunoglobulin (IVIG) at a dose of 400 mg/kg/day was given for 5 days. After IVIG, the muscle weakness of the distal upper extremities improved together with increased F wave-evoked frequencies. These effects lasted for a few months. These observations suggest that immune-mediated neural damage partially contributes to O'Sullivan-McLeod syndrome.
AB - We report a case of O'Sullivan-McLeod syndrome in a 59-year-old man, who had experienced slowly progressive weakening of both hands since he was 20 years of age. Mild hyperIgEemia and eosinophilia were present. Nerve conduction studies revealed reduced F wave-evoked frequencies for the median and ulnar nerves. Intravenous immunoglobulin (IVIG) at a dose of 400 mg/kg/day was given for 5 days. After IVIG, the muscle weakness of the distal upper extremities improved together with increased F wave-evoked frequencies. These effects lasted for a few months. These observations suggest that immune-mediated neural damage partially contributes to O'Sullivan-McLeod syndrome.
UR - http://www.scopus.com/inward/record.url?scp=34247341430&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34247341430&partnerID=8YFLogxK
U2 - 10.2169/internalmedicine.46.6221
DO - 10.2169/internalmedicine.46.6221
M3 - Article
C2 - 17443046
AN - SCOPUS:34247341430
VL - 46
SP - 515
EP - 518
JO - Internal Medicine
JF - Internal Medicine
SN - 0918-2918
IS - 8
ER -