Small hepatocellular carcinomas undetected on two-phased incremental computed tomography: Angiographic and clinicopathologic findings

Hiroshi Honda, Kuniyuki Kaneko, Takashi Maeda, Toshirou Kuroiwa, Tatsurou Fukuya, Kengo Yoshimitsu, Hiroyuki Irie, Hitoshi Aibe, Kenji Takenaka, Masazumi Tsuneyoshi, Keizou Sugimachi, Kouji Masuda

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Abstract

RATIONALE AND OBJECTIVES. To elucidate the characteristic clinicopathologic features of hepatocellular carcinomas (HCCs) undetected on two-phased incremental computed tomography (CT). methods. Computed tomographic scans of 115 surgically resected small (≤3 cm) HCCs from 83 patients were performed 45 seconds and 6 minutes after the administration of contrast material. These scans were compared with corresponding angiographic and histopathologic findings. RESULTS. Eighty HCCs (70%) were depicted on the early images; 73 (63%) on the delayed images; and 89 (77%) using two-phased incremental CT. The small HCCs undetected on the early images but seen histologically had the following characteristics: (1) absence of a fibrous capsule, (2) well-differentiated tumor, (3) replacing growth patterns of the tumors, (4) lack of fatty metamorphosis and/or clear cell changes, (5) liy-povascular on angiography. Those not seen on delayed images had the following characteristics: (1) absence of a fibrous capsule, (2) replacing growth patterns, and (3) presence of portal tracts in the tumors. conclusions. The replacing growth pattern and the presence of portal tracts correlate with the undetectability on CT. For HCCs undetected on CT, treatment methods must be considered carefully, because the HCCs may be receiving transsi-nusoidal and portal blood supplies.

Original languageEnglish
Pages (from-to)458-465
Number of pages8
JournalInvestigative Radiology
Volume30
Issue number8
DOIs
Publication statusPublished - Aug 1995

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Hepatocellular Carcinoma
Tomography
Capsules
Growth
Neoplasms
Contrast Media
Angiography
Therapeutics

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Small hepatocellular carcinomas undetected on two-phased incremental computed tomography : Angiographic and clinicopathologic findings. / Honda, Hiroshi; Kaneko, Kuniyuki; Maeda, Takashi; Kuroiwa, Toshirou; Fukuya, Tatsurou; Yoshimitsu, Kengo; Irie, Hiroyuki; Aibe, Hitoshi; Takenaka, Kenji; Tsuneyoshi, Masazumi; Sugimachi, Keizou; Masuda, Kouji.

In: Investigative Radiology, Vol. 30, No. 8, 08.1995, p. 458-465.

Research output: Contribution to journalArticle

Honda, H, Kaneko, K, Maeda, T, Kuroiwa, T, Fukuya, T, Yoshimitsu, K, Irie, H, Aibe, H, Takenaka, K, Tsuneyoshi, M, Sugimachi, K & Masuda, K 1995, 'Small hepatocellular carcinomas undetected on two-phased incremental computed tomography: Angiographic and clinicopathologic findings', Investigative Radiology, vol. 30, no. 8, pp. 458-465. https://doi.org/10.1097/00004424-199508000-00002
Honda, Hiroshi ; Kaneko, Kuniyuki ; Maeda, Takashi ; Kuroiwa, Toshirou ; Fukuya, Tatsurou ; Yoshimitsu, Kengo ; Irie, Hiroyuki ; Aibe, Hitoshi ; Takenaka, Kenji ; Tsuneyoshi, Masazumi ; Sugimachi, Keizou ; Masuda, Kouji. / Small hepatocellular carcinomas undetected on two-phased incremental computed tomography : Angiographic and clinicopathologic findings. In: Investigative Radiology. 1995 ; Vol. 30, No. 8. pp. 458-465.
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