Small-molecule fluorescent probes for specific RNA targets

Asako Murata; Shin Ichi Sato; Yoshinori Kawazoe; Motonari Uesugi

doi:10.1039/c1cc10393h

Small-molecule fluorescent probes for specific RNA targets

Asako Murata, Shin Ichi Sato, Yoshinori Kawazoe, Motonari Uesugi

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

A method was developed that uses small molecules as fluorescent probes to detect specific mRNAs. In this approach, the fluorescence of fluorophore–quencher conjugates is restored by the binding of an mRNA aptamer tag to the quencher segment of the molecules. The method allows real-time detection of mRNA transcripts in vitro.

Original language	English
Pages (from-to)	4712-4714
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	16
DOIs	https://doi.org/10.1039/c1cc10393h
Publication status	Published - Apr 4 2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c1cc10393h

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title = "Small-molecule fluorescent probes for specific RNA targets",

abstract = "A method was developed that uses small molecules as fluorescent probes to detect specific mRNAs. In this approach, the fluorescence of fluorophore–quencher conjugates is restored by the binding of an mRNA aptamer tag to the quencher segment of the molecules. The method allows real-time detection of mRNA transcripts in vitro.",

author = "Asako Murata and {Ichi Sato}, Shin and Yoshinori Kawazoe and Motonari Uesugi",

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AU - Ichi Sato, Shin

AU - Kawazoe, Yoshinori

AU - Uesugi, Motonari

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AB - A method was developed that uses small molecules as fluorescent probes to detect specific mRNAs. In this approach, the fluorescence of fluorophore–quencher conjugates is restored by the binding of an mRNA aptamer tag to the quencher segment of the molecules. The method allows real-time detection of mRNA transcripts in vitro.

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Small-molecule fluorescent probes for specific RNA targets

Abstract

All Science Journal Classification (ASJC) codes

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