Small molecule-sensing strategy and techniques for understanding the functionality of green tea

Yoshinori Fujimura

    Research output: Contribution to journalReview article

    2 Citations (Scopus)

    Abstract

    Various low-molecular-weight phytochemicals in green tea (Camellia sinensis L.), especially (-)-epigallocatechin- 3-O-gallate (EGCG), are known to be involved in health promotion and disease risk reduction. However, the underlying mechanism has remained elusive because of the absence of an analytical technique that can easily detect the precise behavior of such a small molecule. Recently, we have identified a cell-surface EGCG-sensing receptor and the related signaling molecules that control the physiological functions of EGCG. We also developed a novel in situ label-free imaging technique for visualizing spatially resolved biotransformations based on simultaneous mapping of EGCG and its phase II metabolites. Furthermore, we established a chemometric method capable of evaluating the functionality of multicomponent green tea extracts by focusing on their compositional balances. This review highlights our proposed small molecule-sensing techniques for detecting the complex behavior of green tea components and linking such information to an enhanced understanding of green tea functionality.

    Original languageEnglish
    Pages (from-to)687-699
    Number of pages13
    JournalBioscience, Biotechnology and Biochemistry
    Volume79
    Issue number5
    DOIs
    Publication statusPublished - Jan 1 2015

    Fingerprint

    Tea
    Molecules
    Camellia sinensis
    Phytochemicals
    Risk Reduction Behavior
    Biotransformation
    Metabolites
    Health Promotion
    Labels
    Molecular Weight
    Molecular weight
    Health
    Imaging techniques
    epigallocatechin gallate

    All Science Journal Classification (ASJC) codes

    • Analytical Chemistry
    • Biotechnology
    • Biochemistry
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Organic Chemistry

    Cite this

    Small molecule-sensing strategy and techniques for understanding the functionality of green tea. / Fujimura, Yoshinori.

    In: Bioscience, Biotechnology and Biochemistry, Vol. 79, No. 5, 01.01.2015, p. 687-699.

    Research output: Contribution to journalReview article

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