smyd1 and smyd2 are expressed in muscle tissue in Xenopus laevis

Shinobu Kawamura, Emi Yoshigai, Satoru Kuhara, Kosuke Tashiro

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Epigenetic modifications of histone play important roles for regulation of cell activity, such as cell division, cell death, and cell differentiation. A SET domain consisting of about 130 amino acids has lysine methyltransferase activity in the presence of the cosubstrate S-adenosyl-methionine. More than 60 SET domain-containing proteins have been predicted in various organisms. One of them, the SMYD family genes which contain a SET domain and a zinc-finger MYND domain are reported to regulate cell cycle and muscle formation. Here we examined the expression and function of smyd1 and 2 in Xenopus. smyd1 and 2 were expressed in various muscle tissues. While smyd1 expression was observed mainly in cardiac muscle and skeletal muscle, smyd2 expression was done abundantly in skeletal muscle and face region. Moreover, by loss-of-function experiments using antisense morpholino oligonucleotides, it was suggested that smyd1 and 2 related to muscle cells differentiation.

Original languageEnglish
Pages (from-to)161-168
Number of pages8
JournalCytotechnology
Volume57
Issue number2
DOIs
Publication statusPublished - Jun 1 2008

Fingerprint

Xenopus laevis
Muscle
Cell Differentiation
Skeletal Muscle
Histone Code
Tissue
Morpholinos
Muscles
Antisense Oligonucleotides
Zinc Fingers
Methyltransferases
Xenopus
Cells
Epigenomics
Methionine
Cell Division
Muscle Cells
Lysine
Myocardium
Cell Cycle

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Clinical Biochemistry
  • Cell Biology

Cite this

smyd1 and smyd2 are expressed in muscle tissue in Xenopus laevis. / Kawamura, Shinobu; Yoshigai, Emi; Kuhara, Satoru; Tashiro, Kosuke.

In: Cytotechnology, Vol. 57, No. 2, 01.06.2008, p. 161-168.

Research output: Contribution to journalArticle

Kawamura, Shinobu ; Yoshigai, Emi ; Kuhara, Satoru ; Tashiro, Kosuke. / smyd1 and smyd2 are expressed in muscle tissue in Xenopus laevis. In: Cytotechnology. 2008 ; Vol. 57, No. 2. pp. 161-168.
@article{aeef760e04d34b1f94ed93e739b4a32d,
title = "smyd1 and smyd2 are expressed in muscle tissue in Xenopus laevis",
abstract = "Epigenetic modifications of histone play important roles for regulation of cell activity, such as cell division, cell death, and cell differentiation. A SET domain consisting of about 130 amino acids has lysine methyltransferase activity in the presence of the cosubstrate S-adenosyl-methionine. More than 60 SET domain-containing proteins have been predicted in various organisms. One of them, the SMYD family genes which contain a SET domain and a zinc-finger MYND domain are reported to regulate cell cycle and muscle formation. Here we examined the expression and function of smyd1 and 2 in Xenopus. smyd1 and 2 were expressed in various muscle tissues. While smyd1 expression was observed mainly in cardiac muscle and skeletal muscle, smyd2 expression was done abundantly in skeletal muscle and face region. Moreover, by loss-of-function experiments using antisense morpholino oligonucleotides, it was suggested that smyd1 and 2 related to muscle cells differentiation.",
author = "Shinobu Kawamura and Emi Yoshigai and Satoru Kuhara and Kosuke Tashiro",
year = "2008",
month = "6",
day = "1",
doi = "10.1007/s10616-008-9128-1",
language = "English",
volume = "57",
pages = "161--168",
journal = "Cytotechnology",
issn = "0920-9069",
publisher = "Springer Netherlands",
number = "2",

}

TY - JOUR

T1 - smyd1 and smyd2 are expressed in muscle tissue in Xenopus laevis

AU - Kawamura, Shinobu

AU - Yoshigai, Emi

AU - Kuhara, Satoru

AU - Tashiro, Kosuke

PY - 2008/6/1

Y1 - 2008/6/1

N2 - Epigenetic modifications of histone play important roles for regulation of cell activity, such as cell division, cell death, and cell differentiation. A SET domain consisting of about 130 amino acids has lysine methyltransferase activity in the presence of the cosubstrate S-adenosyl-methionine. More than 60 SET domain-containing proteins have been predicted in various organisms. One of them, the SMYD family genes which contain a SET domain and a zinc-finger MYND domain are reported to regulate cell cycle and muscle formation. Here we examined the expression and function of smyd1 and 2 in Xenopus. smyd1 and 2 were expressed in various muscle tissues. While smyd1 expression was observed mainly in cardiac muscle and skeletal muscle, smyd2 expression was done abundantly in skeletal muscle and face region. Moreover, by loss-of-function experiments using antisense morpholino oligonucleotides, it was suggested that smyd1 and 2 related to muscle cells differentiation.

AB - Epigenetic modifications of histone play important roles for regulation of cell activity, such as cell division, cell death, and cell differentiation. A SET domain consisting of about 130 amino acids has lysine methyltransferase activity in the presence of the cosubstrate S-adenosyl-methionine. More than 60 SET domain-containing proteins have been predicted in various organisms. One of them, the SMYD family genes which contain a SET domain and a zinc-finger MYND domain are reported to regulate cell cycle and muscle formation. Here we examined the expression and function of smyd1 and 2 in Xenopus. smyd1 and 2 were expressed in various muscle tissues. While smyd1 expression was observed mainly in cardiac muscle and skeletal muscle, smyd2 expression was done abundantly in skeletal muscle and face region. Moreover, by loss-of-function experiments using antisense morpholino oligonucleotides, it was suggested that smyd1 and 2 related to muscle cells differentiation.

UR - http://www.scopus.com/inward/record.url?scp=50249122610&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=50249122610&partnerID=8YFLogxK

U2 - 10.1007/s10616-008-9128-1

DO - 10.1007/s10616-008-9128-1

M3 - Article

C2 - 19003161

AN - SCOPUS:50249122610

VL - 57

SP - 161

EP - 168

JO - Cytotechnology

JF - Cytotechnology

SN - 0920-9069

IS - 2

ER -