SNPs in BRAP associated with risk of myocardial infarction in Asian populations

Kouichi Ozaki, Hiroshi Sato, Katsumi Inoue, Tatsuhiko Tsunoda, Yasuhiko Sakata, Hiroya Mizuno, Tsung Hsien Lin, Yoshinari Miyamoto, Asako Aoki, Yoshihiro Onouchi, Sheng Hsiung Sheu, Shiro Ikegawa, Keita Odashiro, Masakiyo Nobuyoshi, Suh Hang H. Juo, Masatsugu Hori, Yusuke Nakamura, Toshihiro Tanaka

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Myocardial infarction is a common disease and among the leading causes of death in the world. We previously reported association of variants in LGALS2, encoding galectin-2, with myocardial infarction susceptibility in a case-control association study in a Japanese population. Here we identify BRAP (BRCA1-associated protein) as a galectin-2-binding protein. We report an association of SNPs in BRAP with myocardial infarction risk in a large Japanese cohort (P = 3.0 × 10-18, OR = 1.48, 2,475 cases and 2,778 controls), with replication in additional Japanese and Taiwanese cohorts (P = 4.4 × 10-6, 862 cases and 1,113 controls and P = 4.7 × 10-3, 349 cases and 994 controls, respectively). BRAP expression was observed in smooth muscle cells (SMCs) and macrophages in human atherosclerotic lesions. BRAP knockdown by siRNA using cultured coronary endothelial cells suppressed activation of NF-κB, a central mediator of inflammation.

Original languageEnglish
Pages (from-to)329-333
Number of pages5
JournalNature genetics
Volume41
Issue number3
DOIs
Publication statusPublished - Mar 1 2009

Fingerprint

BRCA1 Protein
Galectin 2
Single Nucleotide Polymorphism
Myocardial Infarction
Population
Inflammation Mediators
Small Interfering RNA
Smooth Muscle Myocytes
Case-Control Studies
Cause of Death
Carrier Proteins
Endothelial Cells
Macrophages

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Ozaki, K., Sato, H., Inoue, K., Tsunoda, T., Sakata, Y., Mizuno, H., ... Tanaka, T. (2009). SNPs in BRAP associated with risk of myocardial infarction in Asian populations. Nature genetics, 41(3), 329-333. https://doi.org/10.1038/ng.326

SNPs in BRAP associated with risk of myocardial infarction in Asian populations. / Ozaki, Kouichi; Sato, Hiroshi; Inoue, Katsumi; Tsunoda, Tatsuhiko; Sakata, Yasuhiko; Mizuno, Hiroya; Lin, Tsung Hsien; Miyamoto, Yoshinari; Aoki, Asako; Onouchi, Yoshihiro; Sheu, Sheng Hsiung; Ikegawa, Shiro; Odashiro, Keita; Nobuyoshi, Masakiyo; Juo, Suh Hang H.; Hori, Masatsugu; Nakamura, Yusuke; Tanaka, Toshihiro.

In: Nature genetics, Vol. 41, No. 3, 01.03.2009, p. 329-333.

Research output: Contribution to journalArticle

Ozaki, K, Sato, H, Inoue, K, Tsunoda, T, Sakata, Y, Mizuno, H, Lin, TH, Miyamoto, Y, Aoki, A, Onouchi, Y, Sheu, SH, Ikegawa, S, Odashiro, K, Nobuyoshi, M, Juo, SHH, Hori, M, Nakamura, Y & Tanaka, T 2009, 'SNPs in BRAP associated with risk of myocardial infarction in Asian populations', Nature genetics, vol. 41, no. 3, pp. 329-333. https://doi.org/10.1038/ng.326
Ozaki K, Sato H, Inoue K, Tsunoda T, Sakata Y, Mizuno H et al. SNPs in BRAP associated with risk of myocardial infarction in Asian populations. Nature genetics. 2009 Mar 1;41(3):329-333. https://doi.org/10.1038/ng.326
Ozaki, Kouichi ; Sato, Hiroshi ; Inoue, Katsumi ; Tsunoda, Tatsuhiko ; Sakata, Yasuhiko ; Mizuno, Hiroya ; Lin, Tsung Hsien ; Miyamoto, Yoshinari ; Aoki, Asako ; Onouchi, Yoshihiro ; Sheu, Sheng Hsiung ; Ikegawa, Shiro ; Odashiro, Keita ; Nobuyoshi, Masakiyo ; Juo, Suh Hang H. ; Hori, Masatsugu ; Nakamura, Yusuke ; Tanaka, Toshihiro. / SNPs in BRAP associated with risk of myocardial infarction in Asian populations. In: Nature genetics. 2009 ; Vol. 41, No. 3. pp. 329-333.
@article{36833d05ccb94771a1de0b66ca43bd26,
title = "SNPs in BRAP associated with risk of myocardial infarction in Asian populations",
abstract = "Myocardial infarction is a common disease and among the leading causes of death in the world. We previously reported association of variants in LGALS2, encoding galectin-2, with myocardial infarction susceptibility in a case-control association study in a Japanese population. Here we identify BRAP (BRCA1-associated protein) as a galectin-2-binding protein. We report an association of SNPs in BRAP with myocardial infarction risk in a large Japanese cohort (P = 3.0 × 10-18, OR = 1.48, 2,475 cases and 2,778 controls), with replication in additional Japanese and Taiwanese cohorts (P = 4.4 × 10-6, 862 cases and 1,113 controls and P = 4.7 × 10-3, 349 cases and 994 controls, respectively). BRAP expression was observed in smooth muscle cells (SMCs) and macrophages in human atherosclerotic lesions. BRAP knockdown by siRNA using cultured coronary endothelial cells suppressed activation of NF-κB, a central mediator of inflammation.",
author = "Kouichi Ozaki and Hiroshi Sato and Katsumi Inoue and Tatsuhiko Tsunoda and Yasuhiko Sakata and Hiroya Mizuno and Lin, {Tsung Hsien} and Yoshinari Miyamoto and Asako Aoki and Yoshihiro Onouchi and Sheu, {Sheng Hsiung} and Shiro Ikegawa and Keita Odashiro and Masakiyo Nobuyoshi and Juo, {Suh Hang H.} and Masatsugu Hori and Yusuke Nakamura and Toshihiro Tanaka",
year = "2009",
month = "3",
day = "1",
doi = "10.1038/ng.326",
language = "English",
volume = "41",
pages = "329--333",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - SNPs in BRAP associated with risk of myocardial infarction in Asian populations

AU - Ozaki, Kouichi

AU - Sato, Hiroshi

AU - Inoue, Katsumi

AU - Tsunoda, Tatsuhiko

AU - Sakata, Yasuhiko

AU - Mizuno, Hiroya

AU - Lin, Tsung Hsien

AU - Miyamoto, Yoshinari

AU - Aoki, Asako

AU - Onouchi, Yoshihiro

AU - Sheu, Sheng Hsiung

AU - Ikegawa, Shiro

AU - Odashiro, Keita

AU - Nobuyoshi, Masakiyo

AU - Juo, Suh Hang H.

AU - Hori, Masatsugu

AU - Nakamura, Yusuke

AU - Tanaka, Toshihiro

PY - 2009/3/1

Y1 - 2009/3/1

N2 - Myocardial infarction is a common disease and among the leading causes of death in the world. We previously reported association of variants in LGALS2, encoding galectin-2, with myocardial infarction susceptibility in a case-control association study in a Japanese population. Here we identify BRAP (BRCA1-associated protein) as a galectin-2-binding protein. We report an association of SNPs in BRAP with myocardial infarction risk in a large Japanese cohort (P = 3.0 × 10-18, OR = 1.48, 2,475 cases and 2,778 controls), with replication in additional Japanese and Taiwanese cohorts (P = 4.4 × 10-6, 862 cases and 1,113 controls and P = 4.7 × 10-3, 349 cases and 994 controls, respectively). BRAP expression was observed in smooth muscle cells (SMCs) and macrophages in human atherosclerotic lesions. BRAP knockdown by siRNA using cultured coronary endothelial cells suppressed activation of NF-κB, a central mediator of inflammation.

AB - Myocardial infarction is a common disease and among the leading causes of death in the world. We previously reported association of variants in LGALS2, encoding galectin-2, with myocardial infarction susceptibility in a case-control association study in a Japanese population. Here we identify BRAP (BRCA1-associated protein) as a galectin-2-binding protein. We report an association of SNPs in BRAP with myocardial infarction risk in a large Japanese cohort (P = 3.0 × 10-18, OR = 1.48, 2,475 cases and 2,778 controls), with replication in additional Japanese and Taiwanese cohorts (P = 4.4 × 10-6, 862 cases and 1,113 controls and P = 4.7 × 10-3, 349 cases and 994 controls, respectively). BRAP expression was observed in smooth muscle cells (SMCs) and macrophages in human atherosclerotic lesions. BRAP knockdown by siRNA using cultured coronary endothelial cells suppressed activation of NF-κB, a central mediator of inflammation.

UR - http://www.scopus.com/inward/record.url?scp=61349108698&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=61349108698&partnerID=8YFLogxK

U2 - 10.1038/ng.326

DO - 10.1038/ng.326

M3 - Article

C2 - 19198608

AN - SCOPUS:61349108698

VL - 41

SP - 329

EP - 333

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 3

ER -