SOCS-3 regulates onset and maintenance of TH2-mediated allergic responses

Yoh Ichi Seki; Hiromasa Inoue; Naoko Nagata; Katsuhiko Hayashi; Satoru Fukuyama; Koichiro Matsumoto; Okiru Komine; Shinjiro Hamano; Kunisuke Himeno; Kyoko Inagaki-Ohara; Nicholas Cacalano; Anne O'Garra; Tadahilo Oshida; Hirohisa Saito; James A. Johnston; Akihiko Yoshimura; Masato Kubo

doi:10.1038/nm896

SOCS-3 regulates onset and maintenance of T_H2-mediated allergic responses

Yoh Ichi Seki, Hiromasa Inoue, Naoko Nagata, Katsuhiko Hayashi, Satoru Fukuyama, Koichiro Matsumoto, Okiru Komine, Shinjiro Hamano, Kunisuke Himeno, Kyoko Inagaki-Ohara, Nicholas Cacalano, Anne O'Garra, Tadahilo Oshida, Hirohisa Saito, James A. Johnston, Akihiko Yoshimura, Masato Kubo

Research output: Contribution to journal › Article › peer-review

310 Citations (Scopus)

Abstract

Members of the suppressor of cytokine signaling (SOCS) family are involved in the pathogenesis of many inflammatory diseases. SOCS-3 is predominantly expressed in T-helper type 2 (T_H2) cells, but its role in T _H2-related allergic diseases remains to be investigated. In this study we provide a strong correlation between SOCS-3 expression and the pathology of asthma and atopic dermatitis, as well as serum IgE levels in allergic human patients. SOCS-3 transgenic mice showed increased T_H2 responses and multiple pathological features characteristic of asthma in an airway hypersensitivity model system. In contrast, dominant-negative mutant SOCS-3 transgenic mice, as well as mice with a heterozygous deletion of Socs3, had decreased T_H2 development. These data indicate that SOCS-3 has an important role in regulating the onset and maintenance of T _H2-mediated allergic immune disease, and suggest that SOCS-3 may be a new therapeutic target for the development of antiallergic drugs.

Original language	English
Pages (from-to)	1047-1054
Number of pages	8
Journal	Nature medicine
Volume	9
Issue number	8
DOIs	https://doi.org/10.1038/nm896
Publication status	Published - Aug 1 2003
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/nm896

Cite this

Seki, Y. I., Inoue, H., Nagata, N., Hayashi, K., Fukuyama, S., Matsumoto, K., Komine, O., Hamano, S., Himeno, K., Inagaki-Ohara, K., Cacalano, N., O'Garra, A., Oshida, T., Saito, H., Johnston, J. A., Yoshimura, A., & Kubo, M. (2003). SOCS-3 regulates onset and maintenance of T_H2-mediated allergic responses. Nature medicine, 9(8), 1047-1054. https://doi.org/10.1038/nm896

SOCS-3 regulates onset and maintenance of T_H2-mediated allergic responses. / Seki, Yoh Ichi; Inoue, Hiromasa; Nagata, Naoko; Hayashi, Katsuhiko ; Fukuyama, Satoru ; Matsumoto, Koichiro; Komine, Okiru; Hamano, Shinjiro; Himeno, Kunisuke; Inagaki-Ohara, Kyoko; Cacalano, Nicholas; O'Garra, Anne; Oshida, Tadahilo; Saito, Hirohisa; Johnston, James A.; Yoshimura, Akihiko; Kubo, Masato.

In: Nature medicine, Vol. 9, No. 8, 01.08.2003, p. 1047-1054.

Research output: Contribution to journal › Article › peer-review

Seki, Yoh Ichi ; Inoue, Hiromasa ; Nagata, Naoko ; Hayashi, Katsuhiko ; Fukuyama, Satoru ; Matsumoto, Koichiro ; Komine, Okiru ; Hamano, Shinjiro ; Himeno, Kunisuke ; Inagaki-Ohara, Kyoko ; Cacalano, Nicholas ; O'Garra, Anne ; Oshida, Tadahilo ; Saito, Hirohisa ; Johnston, James A. ; Yoshimura, Akihiko ; Kubo, Masato. / SOCS-3 regulates onset and maintenance of T_H2-mediated allergic responses. In: Nature medicine. 2003 ; Vol. 9, No. 8. pp. 1047-1054.

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abstract = "Members of the suppressor of cytokine signaling (SOCS) family are involved in the pathogenesis of many inflammatory diseases. SOCS-3 is predominantly expressed in T-helper type 2 (TH2) cells, but its role in T H2-related allergic diseases remains to be investigated. In this study we provide a strong correlation between SOCS-3 expression and the pathology of asthma and atopic dermatitis, as well as serum IgE levels in allergic human patients. SOCS-3 transgenic mice showed increased TH2 responses and multiple pathological features characteristic of asthma in an airway hypersensitivity model system. In contrast, dominant-negative mutant SOCS-3 transgenic mice, as well as mice with a heterozygous deletion of Socs3, had decreased TH2 development. These data indicate that SOCS-3 has an important role in regulating the onset and maintenance of T H2-mediated allergic immune disease, and suggest that SOCS-3 may be a new therapeutic target for the development of antiallergic drugs.",

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AU - Johnston, James A.

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