Sodium fluxes and astroglial function

Alexei Verkhratsky, Mami Noda, Vladimir Parpura, Sergei Kirischuk

Research output: Chapter in Book/Report/Conference proceedingConference contribution

22 Citations (Scopus)

Abstract

Astrocytes exhibit their excitability based on variations in cytosolic Ca2+ levels, which leads to variety of signalling events. Only recently, however, intracellular fluctuations of more abundant cation Na + are brought in the limelight of glial signalling. Indeed, astrocytes possess several plasmalemmal molecular entities that allow rapid transport of Na+ across the plasma membrane: (1) ionotropic receptors, (2) canonical transient receptor potential cation channels, (3) neurotransmitter transporters and (4) sodium-calcium exchanger. Concerted action of these molecules in controlling cytosolic Na+ may complement Ca2+ signalling to provide basis for complex bidirectional astrocyte-neurone communication at the tripartite synapse.

Original languageEnglish
Title of host publicationSodium Calcium Exchange
Subtitle of host publicationA Growing Spectrum of Pathophysiological Implications: Proceedings of the 6th International Conference on Sodium Calcium Exchange
EditorsLucio Annunziato
Pages295-305
Number of pages11
DOIs
Publication statusPublished - Feb 15 2013

Publication series

NameAdvances in Experimental Medicine and Biology
Volume961
ISSN (Print)0065-2598

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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