Sediment transport and soil loss due to rainfall affect road infrastructure, ecosystem, and agriculture. Interaction between rainfall and soil plays an important role in soil erosion study. Simultaneous effect on soil erosion from rainfall, soil moisture and soil suction under wetting-drying processes has not widely reported in soil erosion research. In this study, laboratory Rainfall-Induced Soil Erosion (RISE) experiments were carried out in order to characterize soil erosion under wetting-drying cycles. Results showed that the wetting-drying rates did not produce similar characteristics of soil erosion even with similar initial conditions of moisture and suction. Increase in the wetting rates coupling with the effect of rainfall intensity on hydro-mechanical properties such as infiltration, moisture, permeability, and suction increased accumulative soil loss. Rate of change in ratios of soil loss-surface runoff and surface runoff-rainfall under the intense rainfall was observed, which could offer viable indicators for physically quantifying soil erosion.