Sol-gel-based bioceramics: From materials to medicine

Bharti Arora, Ji Hoon Park, Eun Ha Choi, Pankaj Attri

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The progress of nanotechnology has opened the path for the development of new biomaterials. Recent developments have demonstrated that sol-gel bioceramics play an important role in the biomedical field due to their superior biological and mechanical properties. A bioactive hydroxyapatite (HA) is a common bioceramic that attaches to living tissues in vivo at body temperature. Sol-gel processes are now being used to produce bioactive coatings, powders, and substrates that can facilitate control over biological behavior of proteins and cells with broad clinical applications. It has been found that HA particles can down-regulate the expression of some cancerogenic genes in 432tumor cells. The nano-HA particles from the biodegradation of HA ceramics could penetrate the membranes of tumor cells. A rapid and economic sol-gel method has been designed to synthesize sodium silicate (Na2SiO3) into silica gel in large quantities. Sol-gel-based bioceramics have the potential to present unexpected excellent biological functions. Thus, the understanding and control of the interactions between bioceramics and biological entities may play one of the leading roles in the development of nanomedicine.

Original languageEnglish
Title of host publicationSmart Ceramics
Subtitle of host publicationPreparation, Properties, and Applications
PublisherPan Stanford Publishing Pte. Ltd.
Pages431-442
Number of pages12
ISBN (Electronic)9781351671644
ISBN (Print)9789814774307
DOIs
Publication statusPublished - Jan 1 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Engineering(all)
  • Materials Science(all)

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