Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: Confirmation of their synonymy

Mahenina Jaovita Manase, Anne Claire Mitaine-Offer, David Pertuit, Tomofumi Miyamoto, Chiaki Tanaka, Stéphanie Delemasure, Patrick Dutartre, Jean François Mirjolet, Olivier Duchamp, Marie Aleth Lacaille-Dubois

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Abstract

A new spirostanol saponin (1), along with four known saponins, dioscin (2), protodioscin (3), methyl-protodioscin (4), and indioside D (5), and one known steroid glycoalkaloid solamargine (6) were isolated from the two synonymous species, Solanum incanum and S. heteracanthum. The structure of the new saponin was established as (23S,25R)-spirost-5-en-3β,23-diol 3-O-{β-d- xylopyranosyl-(1→2)-O-α-l-rhamnopyranosyl-(1→4) -[O-α-l-rhamnopyranosyl-(1→2)]-β-d-glucopyranoside}, by using a combination of 1D and 2D NMR techniques including 1H, 13C, COSY, TOCSY, NOESY, HSQC and HMBC experiments and by mass spectrometry. The compounds 1, 3, 4 and 5 were evaluated for cytotoxicity against five cancer cell lines and for antioxidant and cytoprotective activity.

Original languageEnglish
Pages (from-to)1115-1119
Number of pages5
JournalFitoterapia
Volume83
Issue number6
DOIs
Publication statusPublished - Sep 1 2012

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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    Manase, M. J., Mitaine-Offer, A. C., Pertuit, D., Miyamoto, T., Tanaka, C., Delemasure, S., Dutartre, P., Mirjolet, J. F., Duchamp, O., & Lacaille-Dubois, M. A. (2012). Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: Confirmation of their synonymy. Fitoterapia, 83(6), 1115-1119. https://doi.org/10.1016/j.fitote.2012.04.024