TY - JOUR
T1 - Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides
T2 - Confirmation of their synonymy
AU - Manase, Mahenina Jaovita
AU - Mitaine-Offer, Anne Claire
AU - Pertuit, David
AU - Miyamoto, Tomofumi
AU - Tanaka, Chiaki
AU - Delemasure, Stéphanie
AU - Dutartre, Patrick
AU - Mirjolet, Jean François
AU - Duchamp, Olivier
AU - Lacaille-Dubois, Marie Aleth
PY - 2012/9/1
Y1 - 2012/9/1
N2 - A new spirostanol saponin (1), along with four known saponins, dioscin (2), protodioscin (3), methyl-protodioscin (4), and indioside D (5), and one known steroid glycoalkaloid solamargine (6) were isolated from the two synonymous species, Solanum incanum and S. heteracanthum. The structure of the new saponin was established as (23S,25R)-spirost-5-en-3β,23-diol 3-O-{β-d- xylopyranosyl-(1→2)-O-α-l-rhamnopyranosyl-(1→4) -[O-α-l-rhamnopyranosyl-(1→2)]-β-d-glucopyranoside}, by using a combination of 1D and 2D NMR techniques including 1H, 13C, COSY, TOCSY, NOESY, HSQC and HMBC experiments and by mass spectrometry. The compounds 1, 3, 4 and 5 were evaluated for cytotoxicity against five cancer cell lines and for antioxidant and cytoprotective activity.
AB - A new spirostanol saponin (1), along with four known saponins, dioscin (2), protodioscin (3), methyl-protodioscin (4), and indioside D (5), and one known steroid glycoalkaloid solamargine (6) were isolated from the two synonymous species, Solanum incanum and S. heteracanthum. The structure of the new saponin was established as (23S,25R)-spirost-5-en-3β,23-diol 3-O-{β-d- xylopyranosyl-(1→2)-O-α-l-rhamnopyranosyl-(1→4) -[O-α-l-rhamnopyranosyl-(1→2)]-β-d-glucopyranoside}, by using a combination of 1D and 2D NMR techniques including 1H, 13C, COSY, TOCSY, NOESY, HSQC and HMBC experiments and by mass spectrometry. The compounds 1, 3, 4 and 5 were evaluated for cytotoxicity against five cancer cell lines and for antioxidant and cytoprotective activity.
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U2 - 10.1016/j.fitote.2012.04.024
DO - 10.1016/j.fitote.2012.04.024
M3 - Article
C2 - 22579841
AN - SCOPUS:84863984193
VL - 83
SP - 1115
EP - 1119
JO - Fitoterapia
JF - Fitoterapia
SN - 0367-326X
IS - 6
ER -
