Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: Confirmation of their synonymy

Mahenina Jaovita Manase; Anne Claire Mitaine-Offer; David Pertuit; Tomofumi Miyamoto; Chiaki Tanaka; Stéphanie Delemasure; Patrick Dutartre; Jean François Mirjolet; Olivier Duchamp; Marie Aleth Lacaille-Dubois

doi:10.1016/j.fitote.2012.04.024

Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: Confirmation of their synonymy

Mahenina Jaovita Manase, Anne Claire Mitaine-Offer, David Pertuit, Tomofumi Miyamoto, Chiaki Tanaka, Stéphanie Delemasure, Patrick Dutartre, Jean François Mirjolet, Olivier Duchamp, Marie Aleth Lacaille-Dubois

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article

20 Citations (Scopus)

Abstract

A new spirostanol saponin (1), along with four known saponins, dioscin (2), protodioscin (3), methyl-protodioscin (4), and indioside D (5), and one known steroid glycoalkaloid solamargine (6) were isolated from the two synonymous species, Solanum incanum and S. heteracanthum. The structure of the new saponin was established as (23S,25R)-spirost-5-en-3β,23-diol 3-O-{β-d- xylopyranosyl-(1→2)-O-α-l-rhamnopyranosyl-(1→4) -[O-α-l-rhamnopyranosyl-(1→2)]-β-d-glucopyranoside}, by using a combination of 1D and 2D NMR techniques including ¹H, ¹³C, COSY, TOCSY, NOESY, HSQC and HMBC experiments and by mass spectrometry. The compounds 1, 3, 4 and 5 were evaluated for cytotoxicity against five cancer cell lines and for antioxidant and cytoprotective activity.

Original language	English
Pages (from-to)	1115-1119
Number of pages	5
Journal	Fitoterapia
Volume	83
Issue number	6
DOIs	https://doi.org/10.1016/j.fitote.2012.04.024
Publication status	Published - Sep 1 2012

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery

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Manase, M. J., Mitaine-Offer, A. C., Pertuit, D., Miyamoto, T., Tanaka, C., Delemasure, S., Dutartre, P., Mirjolet, J. F., Duchamp, O., & Lacaille-Dubois, M. A. (2012). Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: Confirmation of their synonymy. Fitoterapia, 83(6), 1115-1119. https://doi.org/10.1016/j.fitote.2012.04.024

Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides : Confirmation of their synonymy. / Manase, Mahenina Jaovita; Mitaine-Offer, Anne Claire; Pertuit, David; Miyamoto, Tomofumi ; Tanaka, Chiaki; Delemasure, Stéphanie; Dutartre, Patrick; Mirjolet, Jean François; Duchamp, Olivier; Lacaille-Dubois, Marie Aleth.

In: Fitoterapia, Vol. 83, No. 6, 01.09.2012, p. 1115-1119.

Research output: Contribution to journal › Article

Manase, Mahenina Jaovita ; Mitaine-Offer, Anne Claire ; Pertuit, David ; Miyamoto, Tomofumi ; Tanaka, Chiaki ; Delemasure, Stéphanie ; Dutartre, Patrick ; Mirjolet, Jean François ; Duchamp, Olivier ; Lacaille-Dubois, Marie Aleth. / Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides : Confirmation of their synonymy. In: Fitoterapia. 2012 ; Vol. 83, No. 6. pp. 1115-1119.

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