TY - JOUR
T1 - Solid-in-oil dispersion
T2 - A novel core technology for drug delivery systems
AU - Tahara, Yoshiro
AU - Kamiya, Noriho
AU - Goto, Masahiro
N1 - Funding Information:
This work was supported by Japan Society for the Promotion of Science (JSPS) KAKENHI KIBAN S Grant Number 24226019 (to M. Goto), and also by Research Fellowships of the JSPS for Young Scientists (to Y. Tahara).
PY - 2012/11/15
Y1 - 2012/11/15
N2 - Drug delivery systems using a solid-in-oil (S/O) dispersion as a core technology have advanced significantly over the past ten years. A novel, effective and practical preparation method for a S/O dispersion was originally established in 1997 as a tool for enzymatic catalysis in organic media. This oil-based dispersion containing proteins in non-aqueous media had great potential for applications to other research with one of the most successful being its adaptation as a drug delivery system. The history and features of novel processes for preparing S/O dispersions are presented in this article. In addition, recent research into the use of S/O dispersions for innovative oral and skin drug delivery systems is discussed.
AB - Drug delivery systems using a solid-in-oil (S/O) dispersion as a core technology have advanced significantly over the past ten years. A novel, effective and practical preparation method for a S/O dispersion was originally established in 1997 as a tool for enzymatic catalysis in organic media. This oil-based dispersion containing proteins in non-aqueous media had great potential for applications to other research with one of the most successful being its adaptation as a drug delivery system. The history and features of novel processes for preparing S/O dispersions are presented in this article. In addition, recent research into the use of S/O dispersions for innovative oral and skin drug delivery systems is discussed.
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U2 - 10.1016/j.ijpharm.2012.09.007
DO - 10.1016/j.ijpharm.2012.09.007
M3 - Review article
C2 - 22975308
AN - SCOPUS:84867397053
VL - 438
SP - 249
EP - 257
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 1-2
ER -