TY - JOUR
T1 - Soluble E-selectin as a marker of disease activity in atopic dermatitis
AU - Yamashita, N.
AU - Kaneko, S.
AU - Kouro, O.
AU - Furue, M.
AU - Yamamoto, S.
AU - Sakane, T.
N1 - Funding Information:
Supported by 1992-1994 research grants from Allergic Disease Research Committee of Japan, Ministry of Health and Welfare of Japan.
PY - 1997
Y1 - 1997
N2 - Background: Augmentation in the expression of adhesion molecules on endothelial cells can regulate leukocyte migration. These molecules are also shed into the circulation. The level of soluble adhesion molecules in the serum is known to reflect the degree of systemic inflammation, and this level can therefore be used as a marker of inflammation. Objective: To elucidate whether soluble adhesion molecules can be used as the marker of disease severity in atopic dermatitis, we examined the levels of soluble E-selectin, soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule-1 and compared these levels with the patients' symptom scores and their total serum IgE levels. Methods: Fifty-three patients with atopic dermatitis were studied. Soluble adhesion molecules were measured by ELISA. Results: The level of soluble E-selectin was higher in patients with atopic dermatitis than in healthy control subjects (p < 0.01). Moreover, soluble E- selectin is correlated with disease severity (p < 0.01). Soluble E-selectin also reflected the changes in symptom scores. In contrast, there were no differences in soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1 between the patients and control subjects. Conclusion: Soluble E-selectin is a good marker of disease severity and of its activity in atopic dermatitis.
AB - Background: Augmentation in the expression of adhesion molecules on endothelial cells can regulate leukocyte migration. These molecules are also shed into the circulation. The level of soluble adhesion molecules in the serum is known to reflect the degree of systemic inflammation, and this level can therefore be used as a marker of inflammation. Objective: To elucidate whether soluble adhesion molecules can be used as the marker of disease severity in atopic dermatitis, we examined the levels of soluble E-selectin, soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule-1 and compared these levels with the patients' symptom scores and their total serum IgE levels. Methods: Fifty-three patients with atopic dermatitis were studied. Soluble adhesion molecules were measured by ELISA. Results: The level of soluble E-selectin was higher in patients with atopic dermatitis than in healthy control subjects (p < 0.01). Moreover, soluble E- selectin is correlated with disease severity (p < 0.01). Soluble E-selectin also reflected the changes in symptom scores. In contrast, there were no differences in soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1 between the patients and control subjects. Conclusion: Soluble E-selectin is a good marker of disease severity and of its activity in atopic dermatitis.
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U2 - 10.1016/S0091-6749(97)70060-5
DO - 10.1016/S0091-6749(97)70060-5
M3 - Article
C2 - 9058698
AN - SCOPUS:0030907210
VL - 99
SP - 410
EP - 414
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
SN - 0091-6749
IS - 3
ER -