Solvent effects in 5-deazaflavin oxidation as a model for NAD+ dependent enzymes

Seiji Shinkai, Hideo Kuroda, Osamu Manabe

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The oxidation rate of 3,5-di-t-butylsalicyl alcohol by 3-methyl-10-ethyl-5-deazaisoalloxazine was found to be very sensitive to solvent effect, the rate constant in 99 vol% DMF being greater by a factor of 37 than that in 50:50 (v/v) DMF-water mixed solvent. The result suggests the importance of the aprotic nature of the reaction environment during the oxidation of alcohols by NAD+.

Original languageEnglish
Pages (from-to)1357-1360
Number of pages4
JournalTetrahedron Letters
Volume23
Issue number13
DOIs
Publication statusPublished - Jan 1 1982
Externally publishedYes

Fingerprint

NAD
Alcohols
Oxidation
Enzymes
Rate constants
Water
5-deazaflavin

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Solvent effects in 5-deazaflavin oxidation as a model for NAD+ dependent enzymes. / Shinkai, Seiji; Kuroda, Hideo; Manabe, Osamu.

In: Tetrahedron Letters, Vol. 23, No. 13, 01.01.1982, p. 1357-1360.

Research output: Contribution to journalArticle

Shinkai, Seiji ; Kuroda, Hideo ; Manabe, Osamu. / Solvent effects in 5-deazaflavin oxidation as a model for NAD+ dependent enzymes. In: Tetrahedron Letters. 1982 ; Vol. 23, No. 13. pp. 1357-1360.
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