Solvent effects in 5-deazaflavin oxidation as a model for NAD+ dependent enzymes

Seiji Shinkai, Hideo Kuroda, Osamu Manabe

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The oxidation rate of 3,5-di-t-butylsalicyl alcohol by 3-methyl-10-ethyl-5-deazaisoalloxazine was found to be very sensitive to solvent effect, the rate constant in 99 vol% DMF being greater by a factor of 37 than that in 50:50 (v/v) DMF-water mixed solvent. The result suggests the importance of the aprotic nature of the reaction environment during the oxidation of alcohols by NAD+.

Original languageEnglish
Pages (from-to)1357-1360
Number of pages4
JournalTetrahedron Letters
Issue number13
Publication statusPublished - Jan 1 1982
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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