TY - JOUR
T1 - Somatic and psychological factors related to the body mass index of patients with anorexia nervosa
AU - Kawai, Keisuke
AU - Yamanaka, T.
AU - Yamashita, S.
AU - Gondo, M.
AU - Morita, C.
AU - Arimura, C.
AU - Nozaki, T.
AU - Takii, M.
AU - Kubo, Chiharu
N1 - Funding Information:
This study was supported by a research grant from the Ministry of Health, Labor and Welfare of Japan (#18590655). We thank the skilled nurses at Kyushu University for their help in carrying out the procedures required for the present study and for analyzing the dietary records of our subjects. We are grateful to Ms. C. Taniguchi for her secretarial assistance. In particular, our study team thanks our patients for their participation. The results of this work were presented in part at the 48th Annual Meeting of the Japanese Society of Psychosomatic Medicine, Fukuoka, Japan, May 2007.
PY - 2008/12
Y1 - 2008/12
N2 - OBJECTIVE: The aim of this study was to examine somatic and psychological factors related to the body mass index (BMI) of anorexia nervosa (AN) patients. METHOD: The analysis was of 24 hospitalized AN patients from the day after admission to the 4th day. The somatic factors analyzed were duration of AN, daily food intake, eating regulatory substances in blood (acylated ghrelin, desacyl ghrelin, leptin), serum cortisol, insulin and estimated creatinine clearance (CCr). The psychological factors analyzed were depression, anxiety, Eating Disorder Inventory (EDI), and hunger/fullness feeling. Measurement of BMI and collection of blood samples were done on the morning after hospitalization. Statistical analysis was by multiple linear regression analysis. RESULTS: BMI showed a reverse correlation with desacyl ghrelin (β=-0.486, p=0.015) and maturity fears (β=-0.375, p=0.046), but was not associated with any other factor by multiple regression analysis. CONCLUSION: The results suggest that desacyl ghrelin and maturity fears play important roles in the prolonged malnutrition state seen in AN patients.
AB - OBJECTIVE: The aim of this study was to examine somatic and psychological factors related to the body mass index (BMI) of anorexia nervosa (AN) patients. METHOD: The analysis was of 24 hospitalized AN patients from the day after admission to the 4th day. The somatic factors analyzed were duration of AN, daily food intake, eating regulatory substances in blood (acylated ghrelin, desacyl ghrelin, leptin), serum cortisol, insulin and estimated creatinine clearance (CCr). The psychological factors analyzed were depression, anxiety, Eating Disorder Inventory (EDI), and hunger/fullness feeling. Measurement of BMI and collection of blood samples were done on the morning after hospitalization. Statistical analysis was by multiple linear regression analysis. RESULTS: BMI showed a reverse correlation with desacyl ghrelin (β=-0.486, p=0.015) and maturity fears (β=-0.375, p=0.046), but was not associated with any other factor by multiple regression analysis. CONCLUSION: The results suggest that desacyl ghrelin and maturity fears play important roles in the prolonged malnutrition state seen in AN patients.
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U2 - 10.1007/BF03327507
DO - 10.1007/BF03327507
M3 - Article
C2 - 19169076
AN - SCOPUS:63849215178
SN - 1124-4909
VL - 13
SP - 198
EP - 204
JO - Eating and Weight Disorders
JF - Eating and Weight Disorders
IS - 4
ER -
