Somatic DNA recombination in a mouse genomic region, BC-1, in brain and non-brain tissue

Toyoki Maeda, Ryuzo Mizuno, Masahiro Sugano, Shinji Satoh, Junichi Oyama, Saburo Sakoda, Tomokazu Suzuki, Naoki Makino

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The genomic region BC-1 (GenBank acc. No. AB075899) on mouse chromosome 16 has been reported as a genomic region undergoing somatic DNA recombination producing circular DNA and genomic deletion in brain during late embryogenesis. The present study shows that the BC-1 circular DNA production had already started on the 13th day of embryonic age, earlier than the previous observation that the circular DNA production started on the 15th through 17th embryonic day. The BC-1 deletion was also observed in the spleen and ocular lens. In situ hybridization analysis indicated that a human-homologous region in the BC-1 sequence was expressed in the lens at a perinatal period. These data suggest that the somatic DNA recombination in the BC-1 region is not restricted to brain tissue, and that the BC-1 DNA recombination relates to lens development.

Original languageEnglish
Pages (from-to)443-449
Number of pages7
JournalCanadian journal of physiology and pharmacology
Volume84
Issue number3-4
DOIs
Publication statusPublished - Mar 2006

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

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