Somatic DNA recombination in the brain

Toyoki Maeda, Saburo Sakoda, Tomokazu Suzuki, Naoki Makino

Research output: Contribution to journalReview article

Abstract

Possible somatic DNA recombination in the brain has been investigated by attempting to capture direct or indirect evidence of it. Until recently, the biological significance of the DNA event, the genes is involved in the recombination, or even whether the event actually occurs in the brain has remained unclear. The DNA-rearranged locus-oriented approach and the recombination activity-oriented approach have mutually contributed to the elucidation of the biological features of extra-immune system somatic DNA recombination. There have been only 2 loci proposed for the candidate, one is a repetitive sequence and the other DNA recombination is nonrepetitive locus. This review states conventional concepts and discussions chronologically and finally to the newest aspects of DNA rearrangement in the brain.

Original languageEnglish
Pages (from-to)319-324
Number of pages6
JournalCanadian journal of physiology and pharmacology
Volume84
Issue number3-4
DOIs
Publication statusPublished - Mar 2006

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

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