Somatic evolution of head and neck cancer - Biological robustness and latent vulnerability

Muneyuki Masuda, Satoshi Toh, Takahiro Wakasaki, Masumi Suzui, Andrew K. Joe

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Despite recent advancements in multidisciplinary treatments, the overall survival and quality of life of patients with advanced head and neck squamous cell carcinoma (HNSCC) have not improved significantly over the past decade. Molecular targeted therapies, which have been addressed and advanced by the concept of " oncogene addiction" , have demonstrated only limited successes so far. To explore a novel clue for clinically effective targeted therapies, we analyzed the molecular circuitry of HNSCC through the lens that HNSCC is an evolving system. In the trajectory of this somatic evolution, HNSCC acquires biological robustness under a variety of selective pressures including genetic, epigenetic, micro-environmental and metabolic stressors, which well explains the major mechanism of " escaping from oncogene addiction" . On the other hand, this systemic view appears to instruct us approaches to target latent vulnerability of HNSCC that is masked behind the plasticity and evolvability of this complex adaptive system.

Original languageEnglish
Pages (from-to)14-28
Number of pages15
JournalMolecular Oncology
Volume7
Issue number1
DOIs
Publication statusPublished - Feb 2013

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Clonal Evolution
Head and Neck Neoplasms
Molecular Targeted Therapy
Oncogenes
Epigenomics
Lenses
Quality of Life
Carcinoma, squamous cell of head and neck
Survival

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Genetics
  • Oncology
  • Cancer Research

Cite this

Somatic evolution of head and neck cancer - Biological robustness and latent vulnerability. / Masuda, Muneyuki; Toh, Satoshi; Wakasaki, Takahiro; Suzui, Masumi; Joe, Andrew K.

In: Molecular Oncology, Vol. 7, No. 1, 02.2013, p. 14-28.

Research output: Contribution to journalReview article

Masuda, Muneyuki ; Toh, Satoshi ; Wakasaki, Takahiro ; Suzui, Masumi ; Joe, Andrew K. / Somatic evolution of head and neck cancer - Biological robustness and latent vulnerability. In: Molecular Oncology. 2013 ; Vol. 7, No. 1. pp. 14-28.
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