Somatosensory amplification and its relationship to somatosensory, auditory, and visual evoked and event-related potentials (P300)

Mutsuhiro Nakao, Arthur J. Barsky, Mariko Nishikitani, Eiji Yano, Katsuyuki Murata

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Somatosensory amplification refers to the tendency to experience benign and ambiguous somatic sensation as intense, noxious, and disturbing. The construct is helpful in assessing the perceptual style of a variety of somatizing conditions, but there is no human study clarifying the effects of neurological function on somatosensory amplification. The present study examines the relationship between somatosensory amplification and different types of evoked potentials. In 33 healthy volunteers (mean age 24 years, 18 men), latencies and amplitudes were recorded using the following parameters: short-latency somatosensory, brainstem-auditory, and visual evoked potentials (SSEP, BAEP, and VEP, respectively) and auditory event-related potentials (ERP). All subjects completed questionnaires for the Somatosensory Amplification Scale (SSAS), 20-item Toronto Alexithymia Scale (TAS-20), and Profile of Mood State (POMS). The SSAS scores were significantly associated with the P200 latency (p = 0.020) and P300 amplitude of ERP (p = 0.041), controlling for the significant effect of the TAS and POMS depression and tension-anxiety scales. The SSEP, BAEP, and VEP latencies or amplitudes were not statistically significant (all p > 0.05). When the subjects were divided into high and low SSAS groups based on the median of the SSAS scores, the P300 amplitude of ERP significantly discriminated the two groups (p = 0.023) by multiple logistic regression analysis. Although the findings should be viewed as preliminary because of the small sample size, somatosensory amplification appears to reflect some aspects of long-latency cognitive processing rather than short-latency interceptive sensitivity from the viewpoint of encephalography.

Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalNeuroscience Letters
Volume415
Issue number2
DOIs
Publication statusPublished - Mar 26 2007
Externally publishedYes

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P300 Event-Related Potentials
Evoked Potentials
Affective Symptoms
Visual Evoked Potentials
Brain Stem Auditory Evoked Potentials
Sample Size
Healthy Volunteers
Anxiety
Logistic Models
Regression Analysis
Depression
Surveys and Questionnaires

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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Somatosensory amplification and its relationship to somatosensory, auditory, and visual evoked and event-related potentials (P300). / Nakao, Mutsuhiro; Barsky, Arthur J.; Nishikitani, Mariko; Yano, Eiji; Murata, Katsuyuki.

In: Neuroscience Letters, Vol. 415, No. 2, 26.03.2007, p. 185-189.

Research output: Contribution to journalArticle

Nakao, Mutsuhiro ; Barsky, Arthur J. ; Nishikitani, Mariko ; Yano, Eiji ; Murata, Katsuyuki. / Somatosensory amplification and its relationship to somatosensory, auditory, and visual evoked and event-related potentials (P300). In: Neuroscience Letters. 2007 ; Vol. 415, No. 2. pp. 185-189.
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