Soy peptide ingestion augments the synthesis and metabolism of noradrenaline in the mouse brain

Haruka Imai, Kazuki Moriyasu, Akane Nakahata, Motohiro Maebuchi, Takashi Ichinose, Shigeki Furuya

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To examine whether edible peptide intake affects neurotransmitter metabolism in the brain, we evaluated the effect of peptides derived from soy proteins or fish collagen on free amino acids and monoamines in the mouse brain. Ingestion of soy peptides led to markedly higher levels of tyrosine, a catecholamine precursor, in the serum, and cerebral cortex compared to those following ingestion of vehicle alone or collagen peptides. Soy peptide ingestion also effectively increased 3-methoxy-4-hydroxyphenylethyleneglycol and normetanephrine, the principal metabolites of noradrenaline, in the cerebral cortex, hippocampus, and brainstem, whereas collagen peptides did not exert such effects. Further, soy peptide ingestion led to a significant increase in noradrenaline itself in the brainstem, where noradrenergic neurons are present. Noradrenergic turnover was also markedly stimulated in these regions after soy peptide ingestion. These in vivo observations suggest that soy peptide ingestion can maintain and promote the synthesis and metabolism of noradrenaline in the brain.

Original languageEnglish
Pages (from-to)1007-1013
Number of pages7
JournalBioscience, Biotechnology and Biochemistry
Volume81
Issue number5
DOIs
Publication statusPublished - 2017

Fingerprint

Metabolism
Brain
Norepinephrine
Eating
Peptides
Collagen
Cerebral Cortex
Brain Stem
Normetanephrine
Adrenergic Neurons
Soybean Proteins
Metabolites
Fish
Neurons
Catecholamines
Neurotransmitter Agents
Tyrosine
Hippocampus
Fishes
Amino Acids

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Soy peptide ingestion augments the synthesis and metabolism of noradrenaline in the mouse brain. / Imai, Haruka; Moriyasu, Kazuki; Nakahata, Akane; Maebuchi, Motohiro; Ichinose, Takashi; Furuya, Shigeki.

In: Bioscience, Biotechnology and Biochemistry, Vol. 81, No. 5, 2017, p. 1007-1013.

Research output: Contribution to journalArticle

Imai, Haruka ; Moriyasu, Kazuki ; Nakahata, Akane ; Maebuchi, Motohiro ; Ichinose, Takashi ; Furuya, Shigeki. / Soy peptide ingestion augments the synthesis and metabolism of noradrenaline in the mouse brain. In: Bioscience, Biotechnology and Biochemistry. 2017 ; Vol. 81, No. 5. pp. 1007-1013.
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