Spatially resolved time-course studies of free radical reactions with an EPRI/MRI fusion technique

Fuminori Hyodo, Keiji Yasukawa, Ken Ichi Yamada, Hideo Utsumi

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Electron paramagnetic resonance imaging (EPRI) using nitroxyl radicals is a useful technique for visualizing reactive oxygen species (ROS) and the pharmacokinetics of probes. To unambiguously identify anatomical locations, coregistration of EPRI with images obtained by MRI is necessary. In this study the feasibility of performing reliable EPRI/MRI fusion imaging using nitroxyl radical fiducial markers was tested. The pharmacokinetics of the nitroxyl radicals were observed after oral or intravenous administration in C57BL6 mice. To fuse both images, the nitroxyl radical was used as fiducial markers. The EPR and MR images corresponded well and clearly illustrated minimal changes in pharmacokinetics between carbamoyl-PROXYL and carboxy-PROXYL. These results demonstrate that the EPRI/MRI fused imaging technique is useful for investigating in vivo pharmacokinetics and provides unambiguous anatomic details.

Original languageEnglish
Pages (from-to)938-943
Number of pages6
JournalMagnetic Resonance in Medicine
Volume56
Issue number4
DOIs
Publication statusPublished - Oct 2006

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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