Species-specific neuronal localization of kynurenine aminotransferase-2 in the mouse cerebellum

Emma Balog, Gyula Jenei, Levente Gellért, Etsuro Ono, László Vécsei, József Toldi, Zsolt Kis

Research output: Contribution to journalArticlepeer-review

Abstract

The immunohistochemical pattern of kynurenine aminotransferase-2 (KAT-2) - the key role enzyme in the production of neuroactive and neuroprotective kynurenic acid (KYNA) - was studied in the cerebellum of mice. It is known from literature that KAT-2 is localized mainly in astrocytes in different parts of the cerebrum. Kynurenine aminotransferase (KAT) activity in the cerebellum is relatively low and alternative production routes for KYNA have been described there. Therefore we examined the immunohistochemical pattern of KAT-2 in this part of the brain. Surprisingly, the cellular localization of KAT-2 in mice was proven to be unique; it localized characteristically in Purkinje cells and in some other types of neurons (not identified) but was not found in astrocytes nor microglia. The exclusive neuronal, but not glial localization of KAT-2 in the cerebellum is novel and may be related to its low activity and to the alternative pathways for KYNA production that have been described.

Original languageEnglish
Article number104920
JournalNeurochemistry International
Volume142
DOIs
Publication statusPublished - Jan 2021

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Cell Biology

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