Species specificity of cytokeratin polypeptide expression in the submandibular gland.

H. Hamakawa, T. Sumida, Y. Bao, H. Tanioka, K. Sogawa, T. Yamada

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6 Citations (Scopus)


Using nine monospecific and seven polyspecific monoclonal antibodies (MoAbs) against cytokeratin (CK), we immunohistochemically studied the species specificity of CK localization in human, rat, mouse, hamster and guinea pig submandibular glands (SMGs). All species showed different staining patterns with various degrees of intensity. The pattern of immunostaining was broadly classified into three groups. Group I showed positive reactivity to the rodent salivary gland, but not to human SMGs (6B10 and 34betaE12). Group 2 showed the reverse staining pattern (M20, A53-B/A2 and Ks19.1). Group 3, for which almost all species were positive, showed interspecific diversity in the staining pattern (CY-90, K8.12, K8.13, C-11 and KH-1). Species specificity of CK should always be taken into consideration when immunohistochemically examining CK expression during development or during carcinogenesis in rodents.

Original languageEnglish
Pages (from-to)265-276
Number of pages12
JournalCellular and molecular biology (Noisy-le-Grand, France)
Issue number2
Publication statusPublished - Mar 1999

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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