Specific fluorescent probe for 8-oxoguanosine

Osamu Nakagawa, Sayaka Ono, Zhichun Li, Akira Tsujimoto, Shigeki Sasaki

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Marking mutations: Complete discrimination of 8-oxoguanosine (8-oxoG) from other nucleosides has been achieved with a new fluorescent probe, named "8-oxoG-clamp" (see picture). The complex structure between 8-oxoG-clamp and 8-oxoG was confirmed by 1H NMR titration and 2D NMR measurements. A preliminary investigation with use of a detergent for solubilization indicates that 8-oxoG-clamp may be applicable in aqueous media.

Original languageEnglish
Pages (from-to)4500-4503
Number of pages4
JournalAngewandte Chemie - International Edition
Volume46
Issue number24
DOIs
Publication statusPublished - Jan 1 2007

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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