Specific recognition of the protein modified with hyaluronan by liver sinusoidal endothelial cells

Shinichi Mochizuki, Arihiro Kano, Asako Yamayoshi, Atsushi Maruyama

Research output: Contribution to conferencePaper

Abstract

It has been reported that LSECs have abilities of high phagocytosis and antigen presentation, and induce immune tolerance to specific antigens. To induce specific immune tolerance, it is thought to be important to deliver antigens to the LSECs precisely. We have studied the targeting to LSECs using HA as ligand, reported the bioconjugates composed of HA. In this report, an antigenic protein, OVA, was modified with hyaluronan to induce the antigen specific immune tolerance through selective delivery of antigen to LSECs.

Original languageEnglish
Pages5177-5178
Number of pages2
Publication statusPublished - Dec 1 2005
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: Sep 20 2005Sep 22 2005

Other

Other54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period9/20/059/22/05

Fingerprint

Endothelial cells
Antigens
Liver
Proteins
Ligands

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Mochizuki, S., Kano, A., Yamayoshi, A., & Maruyama, A. (2005). Specific recognition of the protein modified with hyaluronan by liver sinusoidal endothelial cells. 5177-5178. Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.

Specific recognition of the protein modified with hyaluronan by liver sinusoidal endothelial cells. / Mochizuki, Shinichi; Kano, Arihiro; Yamayoshi, Asako; Maruyama, Atsushi.

2005. 5177-5178 Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.

Research output: Contribution to conferencePaper

Mochizuki, S, Kano, A, Yamayoshi, A & Maruyama, A 2005, 'Specific recognition of the protein modified with hyaluronan by liver sinusoidal endothelial cells' Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan, 9/20/05 - 9/22/05, pp. 5177-5178.
Mochizuki S, Kano A, Yamayoshi A, Maruyama A. Specific recognition of the protein modified with hyaluronan by liver sinusoidal endothelial cells. 2005. Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.
Mochizuki, Shinichi ; Kano, Arihiro ; Yamayoshi, Asako ; Maruyama, Atsushi. / Specific recognition of the protein modified with hyaluronan by liver sinusoidal endothelial cells. Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.2 p.
@conference{547924563e954556b210538ac47fe72a,
title = "Specific recognition of the protein modified with hyaluronan by liver sinusoidal endothelial cells",
abstract = "It has been reported that LSECs have abilities of high phagocytosis and antigen presentation, and induce immune tolerance to specific antigens. To induce specific immune tolerance, it is thought to be important to deliver antigens to the LSECs precisely. We have studied the targeting to LSECs using HA as ligand, reported the bioconjugates composed of HA. In this report, an antigenic protein, OVA, was modified with hyaluronan to induce the antigen specific immune tolerance through selective delivery of antigen to LSECs.",
author = "Shinichi Mochizuki and Arihiro Kano and Asako Yamayoshi and Atsushi Maruyama",
year = "2005",
month = "12",
day = "1",
language = "English",
pages = "5177--5178",
note = "54th SPSJ Symposium on Macromolecules ; Conference date: 20-09-2005 Through 22-09-2005",

}

TY - CONF

T1 - Specific recognition of the protein modified with hyaluronan by liver sinusoidal endothelial cells

AU - Mochizuki, Shinichi

AU - Kano, Arihiro

AU - Yamayoshi, Asako

AU - Maruyama, Atsushi

PY - 2005/12/1

Y1 - 2005/12/1

N2 - It has been reported that LSECs have abilities of high phagocytosis and antigen presentation, and induce immune tolerance to specific antigens. To induce specific immune tolerance, it is thought to be important to deliver antigens to the LSECs precisely. We have studied the targeting to LSECs using HA as ligand, reported the bioconjugates composed of HA. In this report, an antigenic protein, OVA, was modified with hyaluronan to induce the antigen specific immune tolerance through selective delivery of antigen to LSECs.

AB - It has been reported that LSECs have abilities of high phagocytosis and antigen presentation, and induce immune tolerance to specific antigens. To induce specific immune tolerance, it is thought to be important to deliver antigens to the LSECs precisely. We have studied the targeting to LSECs using HA as ligand, reported the bioconjugates composed of HA. In this report, an antigenic protein, OVA, was modified with hyaluronan to induce the antigen specific immune tolerance through selective delivery of antigen to LSECs.

UR - http://www.scopus.com/inward/record.url?scp=33645582031&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645582031&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33645582031

SP - 5177

EP - 5178

ER -