It has been reported that LSECs have abilities of high phagocytosis and antigen presentation, and induce immune tolerance to specific antigens. To induce specific immune tolerance, it is thought to be important to deliver antigens to the LSECs precisely. We have studied the targeting to LSECs using HA as ligand, reported the bioconjugates composed of HA. In this report, an antigenic protein, OVA, was modified with hyaluronan to induce the antigen specific immune tolerance through selective delivery of antigen to LSECs.
|Number of pages||2|
|Publication status||Published - Dec 1 2005|
|Event||54th SPSJ Symposium on Macromolecules - Yamagata, Japan|
Duration: Sep 20 2005 → Sep 22 2005
|Other||54th SPSJ Symposium on Macromolecules|
|Period||9/20/05 → 9/22/05|
All Science Journal Classification (ASJC) codes