Spectaflavoside A, a new potent iron chelating dimeric flavonol glycoside from the rhizomes of Zingiber spectabile Griff.

Yasodha Sivasothy, A. Hamid A. Hadi, Khalit Mohamad, Kok Hoong Leong, Halijah Ibrahim, Shaida Fariza Sulaiman, Kheng Leong Ooi, Khalijah Awang

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7 Citations (Scopus)

Abstract

The rhizomes of Zingiber spectabile yielded a new dimeric flavonol glycoside for which the name kaempferol-3-O-(4″-O-acetyl)-α-l- rhamnopyranoside-(I-6,II-8)-kaempferol-3-O-(4″-O-acetyl) -α-l-rhamnopyranoside; spectaflavoside A (1) was proposed, along with kaempferol and its four acetylrhamnosides (2-6), demethoxycurcumin (7) and curcumin (8). The structure of spectaflavoside A was elucidated by spectroscopic methods including, 1D and 2D NMR techniques. This is the first report on the occurrence of a dimeric flavonol glycoside in the Zingiberaceae and the second in nature. Spectaflavoside A was found to be a potent iron chelating agent.

Original languageEnglish
Pages (from-to)3831-3836
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number11
DOIs
Publication statusPublished - Jun 1 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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    Sivasothy, Y., Hadi, A. H. A., Mohamad, K., Leong, K. H., Ibrahim, H., Sulaiman, S. F., Ooi, K. L., & Awang, K. (2012). Spectaflavoside A, a new potent iron chelating dimeric flavonol glycoside from the rhizomes of Zingiber spectabile Griff. Bioorganic and Medicinal Chemistry Letters, 22(11), 3831-3836. https://doi.org/10.1016/j.bmcl.2012.02.064