Spherical self-assembly of a synthetic α-helical peptide in water

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

A self-assembly of a helical peptide in an aqueous medium was investigated in an attempt to compose a supramolecular structure. A peptide, HA16B, having a hydrophobic α-helical body and a hydrophilic polar head was synthesized and hydrated in water by sonication to obtain a transparent dispersion. Circular dichroism measurement showed that the peptide took an α-helical conformation in the dispersion. Transmission electron microscopy and dynamic light scattering measurement revealed that spherical assemblies were formed with an extremely narrow distribution of size (diameter in the range of 30-40 nm), which is much larger than the molecular length of the peptide. These observations strongly suggest that the peptide assembly took a liposome-like vesicular structure.

Original languageEnglish
Pages (from-to)4377-4379
Number of pages3
JournalLangmuir
Volume15
Issue number13
DOIs
Publication statusPublished - Jan 1 1999

Fingerprint

Self assembly
Peptides
peptides
self assembly
Water
water
Sonication
Liposomes
Dichroism
Dynamic light scattering
assemblies
dichroism
Conformations
light scattering
assembly
Transmission electron microscopy
transmission electron microscopy

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

Cite this

Spherical self-assembly of a synthetic α-helical peptide in water. / Fujita, Katsuhiko.

In: Langmuir, Vol. 15, No. 13, 01.01.1999, p. 4377-4379.

Research output: Contribution to journalArticle

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