Spin-labeled dendrimers in EPR imaging with low molecular weight nitroxides

Alexander T. Yordanov, Ken-Ichi Yamada, Murali C. Krishna, James B. Mitchell, Eric Woller, Mary Cloninger, Martin W. Brechbiel

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Sixth-generation PAMAM dendrimers labeled with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO, shown schematically) have been synthesized and are shown to reoxidize EPR-silent hydroxylamines to EPR-active nitroxides. Therefore these dendrimers are potential TEMPO free radical life supporters for EPR imaging.

Original languageEnglish
Pages (from-to)2690-2692
Number of pages3
JournalAngewandte Chemie - International Edition
Volume40
Issue number14
DOIs
Publication statusPublished - Jul 16 2001
Externally publishedYes

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Dendrimers
Paramagnetic resonance
Molecular weight
Imaging techniques
Hydroxylamines
Free radicals
Free Radicals
TEMPO

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Spin-labeled dendrimers in EPR imaging with low molecular weight nitroxides. / Yordanov, Alexander T.; Yamada, Ken-Ichi; Krishna, Murali C.; Mitchell, James B.; Woller, Eric; Cloninger, Mary; Brechbiel, Martin W.

In: Angewandte Chemie - International Edition, Vol. 40, No. 14, 16.07.2001, p. 2690-2692.

Research output: Contribution to journalArticle

Yordanov, Alexander T. ; Yamada, Ken-Ichi ; Krishna, Murali C. ; Mitchell, James B. ; Woller, Eric ; Cloninger, Mary ; Brechbiel, Martin W. / Spin-labeled dendrimers in EPR imaging with low molecular weight nitroxides. In: Angewandte Chemie - International Edition. 2001 ; Vol. 40, No. 14. pp. 2690-2692.
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