TY - JOUR
T1 - Spinal cord lesions of myelitis with hyperIgEemia and mite antigen specific IgE (atopic myelitis) manifest eosinophilic inflammation
AU - Kikuchi, Hitoshi
AU - Osoegawa, Manabu
AU - Ochi, Hirofumi
AU - Murai, Hiroyuki
AU - Horiuchi, Izumi
AU - Takahashi, Hiroshi
AU - Yamabe, Kazutoshi
AU - Iwaki, Toru
AU - Mizutani, Toshio
AU - Oda, Masaya
AU - Kira, Jun ichi
N1 - Funding Information:
This work was supported in part by Grants Nos. 10470154, 10557062 and 10877099 from the Ministry of Education, Science, Sports and Culture of Japan, and grants from the Neuroimmunological Disease Research Committee and from the Research on Brain Science Committee, the Ministry of Health and Welfare of Japan.
PY - 2001/1/15
Y1 - 2001/1/15
N2 - We report the neuropathological findings of spinal cord specimens obtained from two patients who had localized myelitis with hyperIgEemia and mite antigen specific IgE (atopic myelitis). Both cases showed mild spinal cord dysfunction, and the gadolinium-enhanced area of the isolated spinal cord lesion observed on MRI was biopsied, respectively. Neuropathologically, both cases showed many perivascular lymphocyte cuffings associated with disrupted vessels, and the infiltration of eosinophils in the spinal cord lesions. Both myelin and axons were lost in the lesions, which were associated with astrogliosis. These findings suggest that an allergic mechanism may play a role in this condition.
AB - We report the neuropathological findings of spinal cord specimens obtained from two patients who had localized myelitis with hyperIgEemia and mite antigen specific IgE (atopic myelitis). Both cases showed mild spinal cord dysfunction, and the gadolinium-enhanced area of the isolated spinal cord lesion observed on MRI was biopsied, respectively. Neuropathologically, both cases showed many perivascular lymphocyte cuffings associated with disrupted vessels, and the infiltration of eosinophils in the spinal cord lesions. Both myelin and axons were lost in the lesions, which were associated with astrogliosis. These findings suggest that an allergic mechanism may play a role in this condition.
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U2 - 10.1016/S0022-510X(00)00475-5
DO - 10.1016/S0022-510X(00)00475-5
M3 - Article
C2 - 11166798
AN - SCOPUS:0035862636
SN - 0022-510X
VL - 183
SP - 73
EP - 78
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1
ER -