Spinal cord lesions of myelitis with hyperIgEemia and mite antigen specific IgE (atopic myelitis) manifest eosinophilic inflammation

Hitoshi Kikuchi, Manabu Osoegawa, Hirofumi Ochi, Hiroyuki Murai, Izumi Horiuchi, Hiroshi Takahashi, Kazutoshi Yamabe, Toru Iwaki, Toshio Mizutani, Masaya Oda, Jun ichi Kira

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

We report the neuropathological findings of spinal cord specimens obtained from two patients who had localized myelitis with hyperIgEemia and mite antigen specific IgE (atopic myelitis). Both cases showed mild spinal cord dysfunction, and the gadolinium-enhanced area of the isolated spinal cord lesion observed on MRI was biopsied, respectively. Neuropathologically, both cases showed many perivascular lymphocyte cuffings associated with disrupted vessels, and the infiltration of eosinophils in the spinal cord lesions. Both myelin and axons were lost in the lesions, which were associated with astrogliosis. These findings suggest that an allergic mechanism may play a role in this condition.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalJournal of the Neurological Sciences
Volume183
Issue number1
DOIs
Publication statusPublished - Jan 15 2001

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Spinal cord lesions of myelitis with hyperIgEemia and mite antigen specific IgE (atopic myelitis) manifest eosinophilic inflammation'. Together they form a unique fingerprint.

Cite this