TY - JOUR
T1 - Spinal dorsal horn astrocytes
T2 - New players in chronic itch
AU - Tsuda, Makoto
N1 - Funding Information:
This work was supported by JSPS KAKENHI Grant Numbers 15K15203 , and The Uehara Memorial Foundation .
Publisher Copyright:
© 2016 Japanese Society of Allergology
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Chronic itch is a debilitating symptom of inflammatory skin conditions, such as atopic dermatitis, and systemic diseases, for which existing treatment is largely ineffective. Recent studies have revealed the selective neuronal pathways that are involved in itch sensations; however, the mechanisms by which itch turns into a pathological chronic state are poorly understood. Recent advances in our understanding of the mechanisms producing chronic itch have been made by defining causal roles for astrocytes in the spinal dorsal horn in mouse models of chronic itch including atopic dermatitis. Understanding the key roles of astrocytes may provide us with exciting insights into the mechanisms for itch chronicity and lead to a previously unrecognized target for treating chronic itch.
AB - Chronic itch is a debilitating symptom of inflammatory skin conditions, such as atopic dermatitis, and systemic diseases, for which existing treatment is largely ineffective. Recent studies have revealed the selective neuronal pathways that are involved in itch sensations; however, the mechanisms by which itch turns into a pathological chronic state are poorly understood. Recent advances in our understanding of the mechanisms producing chronic itch have been made by defining causal roles for astrocytes in the spinal dorsal horn in mouse models of chronic itch including atopic dermatitis. Understanding the key roles of astrocytes may provide us with exciting insights into the mechanisms for itch chronicity and lead to a previously unrecognized target for treating chronic itch.
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U2 - 10.1016/j.alit.2016.07.007
DO - 10.1016/j.alit.2016.07.007
M3 - Review article
C2 - 27595395
AN - SCOPUS:84994157722
VL - 66
SP - 31
EP - 35
JO - Allergology International
JF - Allergology International
SN - 1323-8930
IS - 1
ER -