TY - JOUR
T1 - Spinal glial cells in itch modulation
AU - Shiratori-Hayashi, Miho
AU - Makoto, Tsuda
N1 - Funding Information:
This work was supported by JSPS KAKENHI Grant Numbers JP19K22500, JP19H05658, and JP20H05900 (M.T.).
Publisher Copyright:
© 2021 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.
PY - 2021/12
Y1 - 2021/12
N2 - Glial cells are non-neuronal cells in the nervous system that are electrically non-excitable and outnumber neurons in humans. Glial cells have attracted attention in recent years for their active involvement in the regulation of neuronal activity, suggesting their contribution to the pathogenesis and progression of neurological diseases. Studies have shown that astrocytes, a type of glial cell, are activated in the spinal cord in response to skin inflammation and contribute to the exacerbation of chronic itch. This review summarizes the current knowledge about the role of astrocytes and other glial cells in the modulation of itch processing and the mechanism of their activation under itch conditions.
AB - Glial cells are non-neuronal cells in the nervous system that are electrically non-excitable and outnumber neurons in humans. Glial cells have attracted attention in recent years for their active involvement in the regulation of neuronal activity, suggesting their contribution to the pathogenesis and progression of neurological diseases. Studies have shown that astrocytes, a type of glial cell, are activated in the spinal cord in response to skin inflammation and contribute to the exacerbation of chronic itch. This review summarizes the current knowledge about the role of astrocytes and other glial cells in the modulation of itch processing and the mechanism of their activation under itch conditions.
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U2 - 10.1002/prp2.754
DO - 10.1002/prp2.754
M3 - Review article
C2 - 34677000
AN - SCOPUS:85120571703
VL - 9
JO - Pharmacology Research and Perspectives
JF - Pharmacology Research and Perspectives
SN - 2052-1707
IS - 6
M1 - e00754
ER -