Spine-type-specific recruitment of newly synthesized AMPA receptors with learning

Naoki Matsuo, Leon Reijmers, Mark Mayford

Research output: Contribution to journalArticle

209 Citations (Scopus)

Abstract

The stabilization of long-term memories requires de novo protein synthesis. How can proteins, synthesized in the soma, act on specific synapses that participate in a given memory? We studied the dynamics of newly synthesized AMPA-type glutamate receptors (AMPARs) induced with learning using transgenic mice expressing the GluR1 subunit fused to green fluorescent protein (GFP-GluR1) under control of the c-fos promoter. We found learning-associated recruitment of newly synthesized GFP-GluR1 selectively to mushroom-type spines in adult hippocampal CA1 neurons 24 hours after fear conditioning. Our results are consistent with a "synaptic tagging" model to allow activated synapses to subsequently capture newly synthesized receptor and also demonstrate a critical functional distinction in the mushroom spines with learning.

Original languageEnglish
Pages (from-to)1104-1107
Number of pages4
JournalScience
Volume319
Issue number5866
DOIs
Publication statusPublished - Feb 22 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

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