Split-dose cisplatin and vinorelbine as adjuvant chemotherapy for completely resected non-small cell lung cancer

Fumihiko Hirai, Takashi Seto, Mototsugu Shimokawa, Eiko Inamasu, Ryo Toyozawa, Gouji Toyokawa, Tsukihisa Yoshida, Yoshimasa Shiraishi, Tomoyoshi Takenaka, Masafumi Yamaguchi, Mitsuhiro Takenoyama, Yukito Ichinose

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Abstract

Aim: The aim of the present study was to evaluate the feasibility of, and compliance with a regimen using split-dose cisplatin and vinorelbine (split-CV) as adjuvant chemotherapy in patients with completely resected non-small cell lung cancer (NSCLC). Patiets and Methods: The treatment schedule included cisplatin at 40 mg/m2 and vinorelbine at 25 mg/m2 administered intravenously on days 1 and 8, every three weeks for four cycles. Results: This study included 22 patients (male/female; 12/10) with a median age of 67 (range 50-76) years; 10 had clinical stage II and 12 stage III; 21 had ECOG 0 and 1 patient ECOG 1; 15 patients had adenocarcinoma, 5 squamous cell and 2 adenosquamous carcinoma; 18 patients had undergone lobectomy, 3 pneumonectomy and 1 segmentectomy. Seventeen out of 22 patients (77%) received the planned 4 cycles. The main adverse events were grade 3/4 neutropenia (76%) and anemia (12%). The average total doses of cisplatin and vinorelbine were 285 mg/m2 and 177 mg/m2, respectively. Conclusion: The split-CV regimen is well-tolerated as adjuvant chemotherapy for completely resected NSCLC.

Original languageEnglish
Pages (from-to)927-932
Number of pages6
JournalAnticancer research
Volume34
Issue number2
Publication statusPublished - Feb 1 2014

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Hirai, F., Seto, T., Shimokawa, M., Inamasu, E., Toyozawa, R., Toyokawa, G., Yoshida, T., Shiraishi, Y., Takenaka, T., Yamaguchi, M., Takenoyama, M., & Ichinose, Y. (2014). Split-dose cisplatin and vinorelbine as adjuvant chemotherapy for completely resected non-small cell lung cancer. Anticancer research, 34(2), 927-932.