Abstract
We have developed a new class of helical structures that self-assembled spontaneously in aqueous solution. A phospholipid-nucleoside conjugate containing two long alkyl chains and a nucleotidyl residue, dimyristoyl-5'-phosphatidyl-deoxycytidine (1), has been synthesized, and its self-organization, morphology, and physicochemical properties have been investigated. 1 spontaneously assembled to form two types of helical strands. One consisted of a duplex with a diameter of ≈110 Å and helical pitch of ≈240 Å. The duplex further formed a superhelical structure with a helical pitch of ≈1100 Å. The helix was right-handed. The other consisted of a double duplex whose diameter and helical pitch were much the same as those of the former. The double duplex also formed a right-handed superhelical structure. The superhelical strands were gradually converted into gels at 25 °C. We described the formation process of the superhelical strands and proposed a possible model for their structures.
| Original language | English |
|---|---|
| Pages (from-to) | 4567-4570 |
| Number of pages | 4 |
| Journal | Journal of the American Chemical Society |
| Volume | 111 |
| Issue number | 13 |
| DOIs | |
| Publication status | Published - Jan 1 1989 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Catalysis
- Chemistry(all)
- Biochemistry
- Colloid and Surface Chemistry
Cite this
Spontaneous Formation of Superhelical Strands. / Yanagawa, Hiroshi; Ogawa, Yoko; Furuta, Hiroyuki; Tsuno, Katsushige.
In: Journal of the American Chemical Society, Vol. 111, No. 13, 01.01.1989, p. 4567-4570.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Spontaneous Formation of Superhelical Strands
AU - Yanagawa, Hiroshi
AU - Ogawa, Yoko
AU - Furuta, Hiroyuki
AU - Tsuno, Katsushige
PY - 1989/1/1
Y1 - 1989/1/1
N2 - We have developed a new class of helical structures that self-assembled spontaneously in aqueous solution. A phospholipid-nucleoside conjugate containing two long alkyl chains and a nucleotidyl residue, dimyristoyl-5'-phosphatidyl-deoxycytidine (1), has been synthesized, and its self-organization, morphology, and physicochemical properties have been investigated. 1 spontaneously assembled to form two types of helical strands. One consisted of a duplex with a diameter of ≈110 Å and helical pitch of ≈240 Å. The duplex further formed a superhelical structure with a helical pitch of ≈1100 Å. The helix was right-handed. The other consisted of a double duplex whose diameter and helical pitch were much the same as those of the former. The double duplex also formed a right-handed superhelical structure. The superhelical strands were gradually converted into gels at 25 °C. We described the formation process of the superhelical strands and proposed a possible model for their structures.
AB - We have developed a new class of helical structures that self-assembled spontaneously in aqueous solution. A phospholipid-nucleoside conjugate containing two long alkyl chains and a nucleotidyl residue, dimyristoyl-5'-phosphatidyl-deoxycytidine (1), has been synthesized, and its self-organization, morphology, and physicochemical properties have been investigated. 1 spontaneously assembled to form two types of helical strands. One consisted of a duplex with a diameter of ≈110 Å and helical pitch of ≈240 Å. The duplex further formed a superhelical structure with a helical pitch of ≈1100 Å. The helix was right-handed. The other consisted of a double duplex whose diameter and helical pitch were much the same as those of the former. The double duplex also formed a right-handed superhelical structure. The superhelical strands were gradually converted into gels at 25 °C. We described the formation process of the superhelical strands and proposed a possible model for their structures.
UR - http://www.scopus.com/inward/record.url?scp=33845185117&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845185117&partnerID=8YFLogxK
U2 - 10.1021/ja00195a006
DO - 10.1021/ja00195a006
M3 - Article
AN - SCOPUS:33845185117
VL - 111
SP - 4567
EP - 4570
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 13
ER -