Spontaneous Formation of Superhelical Strands

Hiroshi Yanagawa, Yoko Ogawa, Hiroyuki Furuta, Katsushige Tsuno

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

We have developed a new class of helical structures that self-assembled spontaneously in aqueous solution. A phospholipid-nucleoside conjugate containing two long alkyl chains and a nucleotidyl residue, dimyristoyl-5'-phosphatidyl-deoxycytidine (1), has been synthesized, and its self-organization, morphology, and physicochemical properties have been investigated. 1 spontaneously assembled to form two types of helical strands. One consisted of a duplex with a diameter of ≈110 Å and helical pitch of ≈240 Å. The duplex further formed a superhelical structure with a helical pitch of ≈1100 Å. The helix was right-handed. The other consisted of a double duplex whose diameter and helical pitch were much the same as those of the former. The double duplex also formed a right-handed superhelical structure. The superhelical strands were gradually converted into gels at 25 °C. We described the formation process of the superhelical strands and proposed a possible model for their structures.

Original languageEnglish
Pages (from-to)4567-4570
Number of pages4
JournalJournal of the American Chemical Society
Volume111
Issue number13
DOIs
Publication statusPublished - Jan 1 1989
Externally publishedYes

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Deoxycytidine
Phospholipids
Nucleosides
Gels

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Spontaneous Formation of Superhelical Strands. / Yanagawa, Hiroshi; Ogawa, Yoko; Furuta, Hiroyuki; Tsuno, Katsushige.

In: Journal of the American Chemical Society, Vol. 111, No. 13, 01.01.1989, p. 4567-4570.

Research output: Contribution to journalArticle

Yanagawa, Hiroshi ; Ogawa, Yoko ; Furuta, Hiroyuki ; Tsuno, Katsushige. / Spontaneous Formation of Superhelical Strands. In: Journal of the American Chemical Society. 1989 ; Vol. 111, No. 13. pp. 4567-4570.
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