Spontaneous massive necrosis of hepatocellular carcinoma with narrowing and occlusion of the arteries and portal veins

Takahiro Tomino, Yo Ichi Yamashita, Tomohiro Iguchi, Shinji Itoh, Mizuki Ninomiya, Toru Ikegami, Tomoharu Yoshizumi, Yuji Soejima, Hirofumi Kawanaka, Tetsuo Ikeda, Shinichi Aishima, Ken Shirabe, Yoshihiko Maehara

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We herein present the case of a 77-year-old man who had fever and right hypochondriac pain. He visited his doctor and underwent contrast computed tomography (CT), and he was suspected to have a liver abscess. He received an antibiotic treatment and his symptoms soon disappeared, but the tumor did not get smaller and its density on contrast CT image got stronger. He underwent biopsy and moderately differentiated hepatocellular carcinoma (HCC) was found. Extended left hepatic and caudate lobectomy was performed. Histological examination showed moderately differentiated HCC with narrowing and occlusion both in the arteries and portal veins associated with mild chronic inflammation. The mechanisms of spontaneous regression of HCC, such as immunological reactions and tumor hypoxia, have been proposed. In our case, histological examination showed the same findings. However, the mechanism is complex, and therefore further investigations are essential to elucidate it.

Original languageEnglish
Pages (from-to)148-155
Number of pages8
JournalCase Reports in Gastroenterology
Volume8
Issue number1
DOIs
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Fingerprint Dive into the research topics of 'Spontaneous massive necrosis of hepatocellular carcinoma with narrowing and occlusion of the arteries and portal veins'. Together they form a unique fingerprint.

  • Cite this

    Tomino, T., Yamashita, Y. I., Iguchi, T., Itoh, S., Ninomiya, M., Ikegami, T., Yoshizumi, T., Soejima, Y., Kawanaka, H., Ikeda, T., Aishima, S., Shirabe, K., & Maehara, Y. (2014). Spontaneous massive necrosis of hepatocellular carcinoma with narrowing and occlusion of the arteries and portal veins. Case Reports in Gastroenterology, 8(1), 148-155. https://doi.org/10.1159/000362440