Spontaneous regression of breast cancer with axillary lymph node metastasis: A case report and review of literature

Eriko Tokunaga, Shinji Okano, Yuichiro Nakashima, Nami Yamashita, Kimihiro Tanaka, Sauri Akiyoshi, Kenji Taketani, Mitsunori Shirouzu, Hidetaka Yamamoto, Masaru Morita, Yoshihiko Maehara

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Spontaneous regression (SR) of cancer is a rare but well-documented biological phenomenon. However, the mechanism remains to be elucidated. We herein report a case of the SR of breast cancer at both the primary site and metastatic axillary lymph node with spontaneously-induced T cell-mediated immunological responses. A 52-year-old female with a lump in the left axilla was diagnosed to have a small breast carcinoma with a distinct axillary lymph node metastasis. During the preoperative systemic examination, she was diagnosed to have severe type 2 diabetes mellitus, was treated with insulin, and the hyperglycemia was normalized after one month. Surgery for left breast cancer was then performed. The postoperative histopathological examination revealed the SR of breast cancer at both the primary site and metastatic axillary lymph node. Immunohistochemical studies revealed that estrogen receptor positive, AE1/AE3-positive ductal carcinoma completely underwent necrosis associated with extensive infiltration of CD3-positive T cells in the tumor nodule in the lymph node. In addition, primary ductal carcinoma cells also underwent single cell necrosis with infiltration of T cells with lymph follicle-like organization of B cells in the mammary gland. The features were suggestive that the tumor eradication in the metastatic lymph node and regression of the primary ductal carcinoma could be due to host T cell response to the ductal carcinoma. As far as we know it is the first report that shows the spontaneous regression of breast cancer, probably due to the spontaneously-induced T cell response.

Original languageEnglish
Pages (from-to)4371-4380
Number of pages10
JournalInternational Journal of Clinical and Experimental Pathology
Volume7
Issue number7
Publication statusPublished - Jan 1 2014

Fingerprint

Ductal Carcinoma
Lymph Nodes
Breast Neoplasms
Neoplasm Metastasis
T-Lymphocytes
Necrosis
Biological Phenomena
Neoplasms
Axilla
Lymph
Human Mammary Glands
Hyperglycemia
Estrogen Receptors
Type 2 Diabetes Mellitus
B-Lymphocytes
Insulin

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

Cite this

Spontaneous regression of breast cancer with axillary lymph node metastasis : A case report and review of literature. / Tokunaga, Eriko; Okano, Shinji; Nakashima, Yuichiro; Yamashita, Nami; Tanaka, Kimihiro; Akiyoshi, Sauri; Taketani, Kenji; Shirouzu, Mitsunori; Yamamoto, Hidetaka; Morita, Masaru; Maehara, Yoshihiko.

In: International Journal of Clinical and Experimental Pathology, Vol. 7, No. 7, 01.01.2014, p. 4371-4380.

Research output: Contribution to journalArticle

Tokunaga, Eriko ; Okano, Shinji ; Nakashima, Yuichiro ; Yamashita, Nami ; Tanaka, Kimihiro ; Akiyoshi, Sauri ; Taketani, Kenji ; Shirouzu, Mitsunori ; Yamamoto, Hidetaka ; Morita, Masaru ; Maehara, Yoshihiko. / Spontaneous regression of breast cancer with axillary lymph node metastasis : A case report and review of literature. In: International Journal of Clinical and Experimental Pathology. 2014 ; Vol. 7, No. 7. pp. 4371-4380.
@article{b03794adc4954f7ca2b96ce94c18e7dc,
title = "Spontaneous regression of breast cancer with axillary lymph node metastasis: A case report and review of literature",
abstract = "Spontaneous regression (SR) of cancer is a rare but well-documented biological phenomenon. However, the mechanism remains to be elucidated. We herein report a case of the SR of breast cancer at both the primary site and metastatic axillary lymph node with spontaneously-induced T cell-mediated immunological responses. A 52-year-old female with a lump in the left axilla was diagnosed to have a small breast carcinoma with a distinct axillary lymph node metastasis. During the preoperative systemic examination, she was diagnosed to have severe type 2 diabetes mellitus, was treated with insulin, and the hyperglycemia was normalized after one month. Surgery for left breast cancer was then performed. The postoperative histopathological examination revealed the SR of breast cancer at both the primary site and metastatic axillary lymph node. Immunohistochemical studies revealed that estrogen receptor positive, AE1/AE3-positive ductal carcinoma completely underwent necrosis associated with extensive infiltration of CD3-positive T cells in the tumor nodule in the lymph node. In addition, primary ductal carcinoma cells also underwent single cell necrosis with infiltration of T cells with lymph follicle-like organization of B cells in the mammary gland. The features were suggestive that the tumor eradication in the metastatic lymph node and regression of the primary ductal carcinoma could be due to host T cell response to the ductal carcinoma. As far as we know it is the first report that shows the spontaneous regression of breast cancer, probably due to the spontaneously-induced T cell response.",
author = "Eriko Tokunaga and Shinji Okano and Yuichiro Nakashima and Nami Yamashita and Kimihiro Tanaka and Sauri Akiyoshi and Kenji Taketani and Mitsunori Shirouzu and Hidetaka Yamamoto and Masaru Morita and Yoshihiko Maehara",
year = "2014",
month = "1",
day = "1",
language = "English",
volume = "7",
pages = "4371--4380",
journal = "International Journal of Clinical and Experimental Pathology",
issn = "1936-2625",
publisher = "e-Century Publishing Corporation",
number = "7",

}

TY - JOUR

T1 - Spontaneous regression of breast cancer with axillary lymph node metastasis

T2 - A case report and review of literature

AU - Tokunaga, Eriko

AU - Okano, Shinji

AU - Nakashima, Yuichiro

AU - Yamashita, Nami

AU - Tanaka, Kimihiro

AU - Akiyoshi, Sauri

AU - Taketani, Kenji

AU - Shirouzu, Mitsunori

AU - Yamamoto, Hidetaka

AU - Morita, Masaru

AU - Maehara, Yoshihiko

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Spontaneous regression (SR) of cancer is a rare but well-documented biological phenomenon. However, the mechanism remains to be elucidated. We herein report a case of the SR of breast cancer at both the primary site and metastatic axillary lymph node with spontaneously-induced T cell-mediated immunological responses. A 52-year-old female with a lump in the left axilla was diagnosed to have a small breast carcinoma with a distinct axillary lymph node metastasis. During the preoperative systemic examination, she was diagnosed to have severe type 2 diabetes mellitus, was treated with insulin, and the hyperglycemia was normalized after one month. Surgery for left breast cancer was then performed. The postoperative histopathological examination revealed the SR of breast cancer at both the primary site and metastatic axillary lymph node. Immunohistochemical studies revealed that estrogen receptor positive, AE1/AE3-positive ductal carcinoma completely underwent necrosis associated with extensive infiltration of CD3-positive T cells in the tumor nodule in the lymph node. In addition, primary ductal carcinoma cells also underwent single cell necrosis with infiltration of T cells with lymph follicle-like organization of B cells in the mammary gland. The features were suggestive that the tumor eradication in the metastatic lymph node and regression of the primary ductal carcinoma could be due to host T cell response to the ductal carcinoma. As far as we know it is the first report that shows the spontaneous regression of breast cancer, probably due to the spontaneously-induced T cell response.

AB - Spontaneous regression (SR) of cancer is a rare but well-documented biological phenomenon. However, the mechanism remains to be elucidated. We herein report a case of the SR of breast cancer at both the primary site and metastatic axillary lymph node with spontaneously-induced T cell-mediated immunological responses. A 52-year-old female with a lump in the left axilla was diagnosed to have a small breast carcinoma with a distinct axillary lymph node metastasis. During the preoperative systemic examination, she was diagnosed to have severe type 2 diabetes mellitus, was treated with insulin, and the hyperglycemia was normalized after one month. Surgery for left breast cancer was then performed. The postoperative histopathological examination revealed the SR of breast cancer at both the primary site and metastatic axillary lymph node. Immunohistochemical studies revealed that estrogen receptor positive, AE1/AE3-positive ductal carcinoma completely underwent necrosis associated with extensive infiltration of CD3-positive T cells in the tumor nodule in the lymph node. In addition, primary ductal carcinoma cells also underwent single cell necrosis with infiltration of T cells with lymph follicle-like organization of B cells in the mammary gland. The features were suggestive that the tumor eradication in the metastatic lymph node and regression of the primary ductal carcinoma could be due to host T cell response to the ductal carcinoma. As far as we know it is the first report that shows the spontaneous regression of breast cancer, probably due to the spontaneously-induced T cell response.

UR - http://www.scopus.com/inward/record.url?scp=84906238771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906238771&partnerID=8YFLogxK

M3 - Article

C2 - 25120822

AN - SCOPUS:84906238771

VL - 7

SP - 4371

EP - 4380

JO - International Journal of Clinical and Experimental Pathology

JF - International Journal of Clinical and Experimental Pathology

SN - 1936-2625

IS - 7

ER -