Spontaneous regression of multiple seborrheic keratoses associated with nasal carcinoma

M. Furue, F. Kohda, H. Duan, H. Uchi, Y. Kato, H. Kiryu, T. Koga

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Seborrheic keratoses are very common epidermal neoplasms. We describe a patient with seborrheic keratoses presenting multifocal spontaneous regression. The patient had a concurrent nasal adenoid cystic carcinoma. The simultaneous regression of seborrheic keratoses ceased after total resection of the nasal carcinoma. Histological examination revealed marked infiltration of mononuclear cells, including CD4+, CD8+, CD68+ and cutaneous lymphocyte-associated antigen-positive cells, with profound accumulation of CD1a+ dendritic cells. Although apoptotic keratinocytes were not found in the lesional epidermis by histology, the majority of keratinocytes in the regressing seborrheic keratosis were positively stained by the TUNEL method. We postulate that the internal malignancy may induce spontaneous regression of seborrheic keratoses.

Original languageEnglish
Pages (from-to)705-709
Number of pages5
JournalClinical and Experimental Dermatology
Volume26
Issue number8
DOIs
Publication statusPublished - Nov 28 2001

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Seborrheic Keratosis
Nose
Carcinoma
Keratinocytes
Adenoid Cystic Carcinoma
In Situ Nick-End Labeling
Epidermis
Dendritic Cells
Neoplasms
Histology
Lymphocytes
Antigens
Skin

All Science Journal Classification (ASJC) codes

  • Dermatology

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Spontaneous regression of multiple seborrheic keratoses associated with nasal carcinoma. / Furue, M.; Kohda, F.; Duan, H.; Uchi, H.; Kato, Y.; Kiryu, H.; Koga, T.

In: Clinical and Experimental Dermatology, Vol. 26, No. 8, 28.11.2001, p. 705-709.

Research output: Contribution to journalArticle

Furue, M. ; Kohda, F. ; Duan, H. ; Uchi, H. ; Kato, Y. ; Kiryu, H. ; Koga, T. / Spontaneous regression of multiple seborrheic keratoses associated with nasal carcinoma. In: Clinical and Experimental Dermatology. 2001 ; Vol. 26, No. 8. pp. 705-709.
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