Spontaneous self-assembly of nanospheres from trigonal conjugate of glutathione in water

Kazunori Matsuura, Hironori Matsuyama, Takashi Fukuda, Takeshi Teramoto, Kenta Watanabe, Kazuya Murasato, Nobuo Kimizuka

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Abstract

A novel C3-symmetric peptide conjugate bearing three glutathione units (trigonal-glutathione, TG) was synthesized and its self-assembling behavior in water was studied by dynamic light scattering measurement, electron microscopy, and 1H-NMR spectroscopy. In water, TG showed spontaneous self-assembly into nanospheres with the size of 100-250 nm. The size of TG assemblies is minimally affected by the concentration and pH. Concentration dependence of 1H-NMR chemical shifts in D2O revealed that TG is self-assembled by interactions between glutathione units (hydrogen bonding, electrostatic interactions) with an apparent association constant of Ka = 6.36 × 103 M-1. Concentration dependence of light scattering intensity and guest-binding ability indicated that the nanospheres underwent structural changes from hollow to filled spheres depending on the concentration.

Original languageEnglish
Pages (from-to)2463-2470
Number of pages8
JournalSoft Matter
Volume5
Issue number12
DOIs
Publication statusPublished - Jun 24 2009

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

Matsuura, K., Matsuyama, H., Fukuda, T., Teramoto, T., Watanabe, K., Murasato, K., & Kimizuka, N. (2009). Spontaneous self-assembly of nanospheres from trigonal conjugate of glutathione in water. Soft Matter, 5(12), 2463-2470. https://doi.org/10.1039/b819472f