"Sporadic" prealbumin-related amyloid polyneuropathy: report of two cases

M. Yamada, H. Tsukagoshi, J. Satoh, S. Ishiai, M. Nakazato, H. Furuya, H. Sasaki, Y. Sakaki, T. Yokota

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5 Citations (Scopus)

Abstract

Two "sporadic" cases of amyloid polyneuropathy are reported. There was no family history or plasma cell dyscrasia. Both showed sensorimotor and autonomic polyneuropathy with onset in the seventh decade. Amyloid deposits in both cases reacted with anti-human prealbumin sera but not with antisera to human AA and anti-human immunoglobulin light-chain amyloids, including Aκ and Aλ. One patient had the abnormal serum prealbumin and abnormal DNA sequence found in type I familial amyloid polyneuropathy (FAP) (Japanese type). Investigations in "sporadic" amyloid polyneuropathy should include immunohistochemistry, using antisera to the different amyloid proteins, and the radioimmunoassay and recombinant DNA techniques for diagnosis of FAP.

Original languageEnglish
Pages (from-to)69-73
Number of pages5
JournalJournal of Neurology
Volume235
Issue number2
DOIs
Publication statusPublished - Jan 1 1987

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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    Yamada, M., Tsukagoshi, H., Satoh, J., Ishiai, S., Nakazato, M., Furuya, H., Sasaki, H., Sakaki, Y., & Yokota, T. (1987). "Sporadic" prealbumin-related amyloid polyneuropathy: report of two cases. Journal of Neurology, 235(2), 69-73. https://doi.org/10.1007/BF00718012