SPR-based DNA detection with metal nanoparticles

Kaoru Tamada; Fumio Nakamura; Masateru Ito; Xinheng Li; Akira Baba

doi:10.1007/s11468-007-9035-x

SPR-based DNA detection with metal nanoparticles

Kaoru Tamada, Fumio Nakamura, Masateru Ito, Xinheng Li, Akira Baba

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

In this short review paper, we summarize some of our ideas to utilize gold nanoparticles for the enhancement of surface plasmon resonance signals on DNA microarray. The hybridization of target-DNA capped gold nanoparticles with probe DNA on surface provides ca. ten times stronger optical contrast compared with that of target-DNA molecules. Our simulation result based on the Maxwell-Garnet theory explains well our experimental data and proves a potential of metallic nanoparticles for the substantial sensitivity enhancements for biosensor application in DNA diagnostics and bio-affinity studies, which leads to the fabrication of high resolution DNA microarrays.

Original language	English
Pages (from-to)	185-191
Number of pages	7
Journal	Plasmonics
Volume	2
Issue number	4
DOIs	https://doi.org/10.1007/s11468-007-9035-x
Publication status	Published - Dec 2007
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biotechnology
Biophysics
Biochemistry

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author = "Kaoru Tamada and Fumio Nakamura and Masateru Ito and Xinheng Li and Akira Baba",

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AU - Tamada, Kaoru

AU - Nakamura, Fumio

AU - Ito, Masateru

AU - Li, Xinheng

AU - Baba, Akira

PY - 2007/12

Y1 - 2007/12

N2 - In this short review paper, we summarize some of our ideas to utilize gold nanoparticles for the enhancement of surface plasmon resonance signals on DNA microarray. The hybridization of target-DNA capped gold nanoparticles with probe DNA on surface provides ca. ten times stronger optical contrast compared with that of target-DNA molecules. Our simulation result based on the Maxwell-Garnet theory explains well our experimental data and proves a potential of metallic nanoparticles for the substantial sensitivity enhancements for biosensor application in DNA diagnostics and bio-affinity studies, which leads to the fabrication of high resolution DNA microarrays.

AB - In this short review paper, we summarize some of our ideas to utilize gold nanoparticles for the enhancement of surface plasmon resonance signals on DNA microarray. The hybridization of target-DNA capped gold nanoparticles with probe DNA on surface provides ca. ten times stronger optical contrast compared with that of target-DNA molecules. Our simulation result based on the Maxwell-Garnet theory explains well our experimental data and proves a potential of metallic nanoparticles for the substantial sensitivity enhancements for biosensor application in DNA diagnostics and bio-affinity studies, which leads to the fabrication of high resolution DNA microarrays.

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SPR-based DNA detection with metal nanoparticles

Abstract

All Science Journal Classification (ASJC) codes

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