Stable cellular force measurement by on-chip robotic probe by employing surface-directed liquid flow

S. Sakuma, M. Sugita, F. Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper presents a novel on-chip manipulation method of a single cell using a surface-directed liquid flow. In order to avoid the oscillation disturbance due to the motion of on-chip robotic probe, air-liquid interface separated the driving point from the on-chip probe, and only manipulation point approached cell in the microchannel. The surface-directed liquid flow was formed by the nanopillar micropatterns fabricated by the multi-scale patterning technique. Wide range wettability control of the substrate was achieved by changing the density of nanopillars to obtain the robust air-liquid interface. The oscillation of microparticles was dramatically reduced by the surface-directed liquid flow. Finally, the cellular force measurement, which required the stable cell manipulation, was achieved.

Original languageEnglish
Title of host publication2013 Transducers and Eurosensors XXVII
Subtitle of host publicationThe 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013
Pages2213-2216
Number of pages4
DOIs
Publication statusPublished - 2013
Externally publishedYes
Event2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013 - Barcelona, Spain
Duration: Jun 16 2013Jun 20 2013

Publication series

Name2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013

Other

Other2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013
CountrySpain
CityBarcelona
Period6/16/136/20/13

All Science Journal Classification (ASJC) codes

  • Hardware and Architecture
  • Electrical and Electronic Engineering

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