Staphylococcal endocarditis as the first manifestation of heritable protein S deficiency in childhood

Takayuki Hoshina, Yasutaka Nakashima, Daisuke Sato, Etsuro Nanishi, Hisanori Nishio, Hazumu Nagata, Kenichiro Yamamura, Takehiko Doi, Yuichi Shiokawa, Yui Koga, Dongchon Kang, Shoichi Ohga, Toshiro Hara

Research output: Contribution to journalArticle

Abstract

A 12-year-old Japanese girl developed infective endocarditis and central nervous system disease. The previously healthy girl showed altered consciousness and abnormal behaviors along with the classical signs of septic emboli. Staphylococcus aureus was isolated from peripheral blood, but not, the pleocytotic cerebrospinal fluid. Diagnostic imaging studies revealed a vegetative structure in the morphologically normal heart, and multiple thromboembolisms in the brain and spleen. Low plasma activity of protein S (12%) and thrombophilic family history allowed the genetic study, demonstrating that she carried a heterozygous mutation of PROS1 (exon 13; 1689C > T, p.R474C). Surgical intervention of the thrombotic fibrous organization and subsequent anticoagulant therapy successfully managed the disease. There are no reports of infective endocarditis in childhood occurring as the first presentation of heritable thrombophilia. Protein S deficiency might be a risk factor for the development or exacerbation of infective endocarditis in children having no pre-existing heart disease.

Original languageEnglish
Pages (from-to)128-130
Number of pages3
JournalJournal of Infection and Chemotherapy
Volume20
Issue number2
DOIs
Publication statusPublished - Jan 1 2014

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Protein S Deficiency
Endocarditis
Preexisting Condition Coverage
Thrombophilia
Central Nervous System Diseases
Protein S
Thromboembolism
Diagnostic Imaging
Embolism
Consciousness
Anticoagulants
Cerebrospinal Fluid
Staphylococcus aureus
Blood Proteins
Exons
Heart Diseases
Spleen
Organizations
Mutation
Brain

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Staphylococcal endocarditis as the first manifestation of heritable protein S deficiency in childhood. / Hoshina, Takayuki; Nakashima, Yasutaka; Sato, Daisuke; Nanishi, Etsuro; Nishio, Hisanori; Nagata, Hazumu; Yamamura, Kenichiro; Doi, Takehiko; Shiokawa, Yuichi; Koga, Yui; Kang, Dongchon; Ohga, Shoichi; Hara, Toshiro.

In: Journal of Infection and Chemotherapy, Vol. 20, No. 2, 01.01.2014, p. 128-130.

Research output: Contribution to journalArticle

Hoshina, Takayuki ; Nakashima, Yasutaka ; Sato, Daisuke ; Nanishi, Etsuro ; Nishio, Hisanori ; Nagata, Hazumu ; Yamamura, Kenichiro ; Doi, Takehiko ; Shiokawa, Yuichi ; Koga, Yui ; Kang, Dongchon ; Ohga, Shoichi ; Hara, Toshiro. / Staphylococcal endocarditis as the first manifestation of heritable protein S deficiency in childhood. In: Journal of Infection and Chemotherapy. 2014 ; Vol. 20, No. 2. pp. 128-130.
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