Start of μ-chain production by the further two-step rearrangements of immunoglobulin heavy chain genes on one chromosome from a DJ(H)/DJ(H) configuration in an Abelson virus-transformed cell line: Evidence of secondary DJ(H) complex formation

T. Maeda, H. Sugiyama, Y. Tani, S. Miyake, Y. Oka, H. Ogawa, T. Komori, T. Soma, S. Kishimoto

Research output: Contribution to journalArticle

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Abstract

A variant was selected from an Abelson virus-transformed cell line with identifiable and distinguishable DJ(H) rearrangements on both chromosomes. Southern blotting experiments suggested that this variant resulted from a secondary DJ(H) complex formation accompanied with the deletion of one of the DJ(H) rearrangements on the same chromosome. Furthermore, this variant started making μ-chains by the further functional join of a V(H) gene to the secondarily formed DJ(H) complex. Thus, we describe here the first evidence of a secondary DJ(H) complex formation.

Original languageEnglish
Pages (from-to)2305-2310
Number of pages6
JournalJournal of Immunology
Volume138
Issue number7
Publication statusPublished - May 27 1987
Externally publishedYes

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Immunoglobulin Heavy Chain Genes
Transformed Cell Line
Chromosomes
Viruses
Southern Blotting
Genes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Start of μ-chain production by the further two-step rearrangements of immunoglobulin heavy chain genes on one chromosome from a DJ(H)/DJ(H) configuration in an Abelson virus-transformed cell line : Evidence of secondary DJ(H) complex formation. / Maeda, T.; Sugiyama, H.; Tani, Y.; Miyake, S.; Oka, Y.; Ogawa, H.; Komori, T.; Soma, T.; Kishimoto, S.

In: Journal of Immunology, Vol. 138, No. 7, 27.05.1987, p. 2305-2310.

Research output: Contribution to journalArticle

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AU - Maeda, T.

AU - Sugiyama, H.

AU - Tani, Y.

AU - Miyake, S.

AU - Oka, Y.

AU - Ogawa, H.

AU - Komori, T.

AU - Soma, T.

AU - Kishimoto, S.

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