Start of μ-chain production by the further two-step rearrangements of immunoglobulin heavy chain genes on one chromosome from a DJ(H)/DJ(H) configuration in an Abelson virus-transformed cell line: Evidence of secondary DJ(H) complex formation

T. Maeda, H. Sugiyama, Y. Tani, S. Miyake, Y. Oka, H. Ogawa, T. Komori, T. Soma, S. Kishimoto

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A variant was selected from an Abelson virus-transformed cell line with identifiable and distinguishable DJ(H) rearrangements on both chromosomes. Southern blotting experiments suggested that this variant resulted from a secondary DJ(H) complex formation accompanied with the deletion of one of the DJ(H) rearrangements on the same chromosome. Furthermore, this variant started making μ-chains by the further functional join of a V(H) gene to the secondarily formed DJ(H) complex. Thus, we describe here the first evidence of a secondary DJ(H) complex formation.

Original languageEnglish
Pages (from-to)2305-2310
Number of pages6
JournalJournal of Immunology
Volume138
Issue number7
Publication statusPublished - May 27 1987
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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