Abstract
Background: Iron uptake through the transferrin-dependent pathway is essential for osteoclast differentiation. Results: Knocking down the expression of Steap4, an endosomal ferrireductase, inhibits osteoclast formation and decreases cellular iron and ROS production. Conclusion: Steap4 regulates cellular iron metabolism during osteoclast differentiation. Significance: This work provides new insights into the molecular mechanisms regulating cellular iron metabolism in osteoclast lineage cells.
| Original language | English |
|---|---|
| Pages (from-to) | 30064-30074 |
| Number of pages | 11 |
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 42 |
| DOIs | |
| Publication status | Published - Oct 18 2013 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
- Cell Biology
Cite this
Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation. / Zhou, Jian; Ye, Shiqiao; Fujiwara, Toshifumi; Manolagas, Stavros C.; Zhao, Haibo.
In: Journal of Biological Chemistry, Vol. 288, No. 42, 18.10.2013, p. 30064-30074.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation
AU - Zhou, Jian
AU - Ye, Shiqiao
AU - Fujiwara, Toshifumi
AU - Manolagas, Stavros C.
AU - Zhao, Haibo
PY - 2013/10/18
Y1 - 2013/10/18
N2 - Background: Iron uptake through the transferrin-dependent pathway is essential for osteoclast differentiation. Results: Knocking down the expression of Steap4, an endosomal ferrireductase, inhibits osteoclast formation and decreases cellular iron and ROS production. Conclusion: Steap4 regulates cellular iron metabolism during osteoclast differentiation. Significance: This work provides new insights into the molecular mechanisms regulating cellular iron metabolism in osteoclast lineage cells.
AB - Background: Iron uptake through the transferrin-dependent pathway is essential for osteoclast differentiation. Results: Knocking down the expression of Steap4, an endosomal ferrireductase, inhibits osteoclast formation and decreases cellular iron and ROS production. Conclusion: Steap4 regulates cellular iron metabolism during osteoclast differentiation. Significance: This work provides new insights into the molecular mechanisms regulating cellular iron metabolism in osteoclast lineage cells.
UR - http://www.scopus.com/inward/record.url?scp=84886880324&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886880324&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.478750
DO - 10.1074/jbc.M113.478750
M3 - Article
C2 - 23990467
AN - SCOPUS:84886880324
VL - 288
SP - 30064
EP - 30074
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 42
ER -