Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation

Jian Zhou; Shiqiao Ye; Toshifumi Fujiwara; Stavros C. Manolagas; Haibo Zhao

doi:10.1074/jbc.M113.478750

Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation

Jian Zhou, Shiqiao Ye, Toshifumi Fujiwara, Stavros C. Manolagas, Haibo Zhao

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

Background: Iron uptake through the transferrin-dependent pathway is essential for osteoclast differentiation. Results: Knocking down the expression of Steap4, an endosomal ferrireductase, inhibits osteoclast formation and decreases cellular iron and ROS production. Conclusion: Steap4 regulates cellular iron metabolism during osteoclast differentiation. Significance: This work provides new insights into the molecular mechanisms regulating cellular iron metabolism in osteoclast lineage cells.

Original language	English
Pages (from-to)	30064-30074
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	42
DOIs	https://doi.org/10.1074/jbc.M113.478750
Publication status	Published - Oct 18 2013
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1074/jbc.M113.478750

Fingerprint Dive into the research topics of 'Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation'. Together they form a unique fingerprint.

Cite this

Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation. / Zhou, Jian; Ye, Shiqiao; Fujiwara, Toshifumi; Manolagas, Stavros C.; Zhao, Haibo.

In: Journal of Biological Chemistry, Vol. 288, No. 42, 18.10.2013, p. 30064-30074.

Research output: Contribution to journal › Article › peer-review

@article{d6cf68c2b8944938b88529f3beb754fc,

title = "Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation",

abstract = "Background: Iron uptake through the transferrin-dependent pathway is essential for osteoclast differentiation. Results: Knocking down the expression of Steap4, an endosomal ferrireductase, inhibits osteoclast formation and decreases cellular iron and ROS production. Conclusion: Steap4 regulates cellular iron metabolism during osteoclast differentiation. Significance: This work provides new insights into the molecular mechanisms regulating cellular iron metabolism in osteoclast lineage cells.",

author = "Jian Zhou and Shiqiao Ye and Toshifumi Fujiwara and Manolagas, {Stavros C.} and Haibo Zhao",

year = "2013",

month = oct,

day = "18",

doi = "10.1074/jbc.M113.478750",

language = "English",

volume = "288",

pages = "30064--30074",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "42",

}

TY - JOUR

T1 - Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation

AU - Zhou, Jian

AU - Ye, Shiqiao

AU - Fujiwara, Toshifumi

AU - Manolagas, Stavros C.

AU - Zhao, Haibo

PY - 2013/10/18

Y1 - 2013/10/18

N2 - Background: Iron uptake through the transferrin-dependent pathway is essential for osteoclast differentiation. Results: Knocking down the expression of Steap4, an endosomal ferrireductase, inhibits osteoclast formation and decreases cellular iron and ROS production. Conclusion: Steap4 regulates cellular iron metabolism during osteoclast differentiation. Significance: This work provides new insights into the molecular mechanisms regulating cellular iron metabolism in osteoclast lineage cells.

AB - Background: Iron uptake through the transferrin-dependent pathway is essential for osteoclast differentiation. Results: Knocking down the expression of Steap4, an endosomal ferrireductase, inhibits osteoclast formation and decreases cellular iron and ROS production. Conclusion: Steap4 regulates cellular iron metabolism during osteoclast differentiation. Significance: This work provides new insights into the molecular mechanisms regulating cellular iron metabolism in osteoclast lineage cells.

UR - http://www.scopus.com/inward/record.url?scp=84886880324&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886880324&partnerID=8YFLogxK

U2 - 10.1074/jbc.M113.478750

DO - 10.1074/jbc.M113.478750

M3 - Article

C2 - 23990467

AN - SCOPUS:84886880324

VL - 288

SP - 30064

EP - 30074

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 42

ER -