TY - JOUR
T1 - Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation
AU - Zhou, Jian
AU - Ye, Shiqiao
AU - Fujiwara, Toshifumi
AU - Manolagas, Stavros C.
AU - Zhao, Haibo
PY - 2013/10/18
Y1 - 2013/10/18
N2 - Background: Iron uptake through the transferrin-dependent pathway is essential for osteoclast differentiation. Results: Knocking down the expression of Steap4, an endosomal ferrireductase, inhibits osteoclast formation and decreases cellular iron and ROS production. Conclusion: Steap4 regulates cellular iron metabolism during osteoclast differentiation. Significance: This work provides new insights into the molecular mechanisms regulating cellular iron metabolism in osteoclast lineage cells.
AB - Background: Iron uptake through the transferrin-dependent pathway is essential for osteoclast differentiation. Results: Knocking down the expression of Steap4, an endosomal ferrireductase, inhibits osteoclast formation and decreases cellular iron and ROS production. Conclusion: Steap4 regulates cellular iron metabolism during osteoclast differentiation. Significance: This work provides new insights into the molecular mechanisms regulating cellular iron metabolism in osteoclast lineage cells.
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U2 - 10.1074/jbc.M113.478750
DO - 10.1074/jbc.M113.478750
M3 - Article
C2 - 23990467
AN - SCOPUS:84886880324
VL - 288
SP - 30064
EP - 30074
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 42
ER -