Stem cell property of postmigratory cranial neural crest cells and their utility in alveolar bone regeneration and tooth development

Il Hyuk Chung, Takayoshi Yamaza, Hu Zhao, Pill Hoon Choung, Songtao Shi, Yang Chai

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The vertebrate neural crest is a multipotent cell population that gives rise to a variety of different cell types. We have discovered that postmigratory cranial neural crest cells (CNCCs) maintain mesenchymal stem cell characteristics and show potential utility for the regeneration of craniofacial structures. We are able to induce the osteogenic differentiation of postmigratory CNCCs, and this differentiation is regulated by bone morphogenetic protein (BMP) and transforming growth factor-b signaling pathways. After transplantation into a host animal, postmigratory CNCCs form bone matrix. CNCC-formed bones are distinct from bones regenerated by bone marrow mesenchymal stem cells. In addition, CNCCs support tooth germ survival via BMP signaling in our CNCC-tooth germ cotransplantation system. Thus, we conclude that postmigratory CNCCs preserve stem cell features, contribute to craniofacial bone formation, and play a fundamental role in supporting tooth organ development. These findings reveal a novel function for postmigratory CNCCs in organ development, and demonstrate the utility of these CNCCs in regenerating craniofacial structures.

Original languageEnglish
Pages (from-to)866-877
Number of pages12
JournalSTEM CELLS
Volume27
Issue number4
DOIs
Publication statusPublished - Apr 1 2009
Externally publishedYes

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Bone Regeneration
Neural Crest
Tooth
Stem Cells
Tooth Germ
Bone Morphogenetic Proteins
Mesenchymal Stromal Cells
Bone and Bones
Bone Matrix
Transforming Growth Factors
Osteogenesis
Vertebrates
Regeneration
Cell Differentiation
Transplantation
Bone Marrow

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

Cite this

Stem cell property of postmigratory cranial neural crest cells and their utility in alveolar bone regeneration and tooth development. / Chung, Il Hyuk; Yamaza, Takayoshi; Zhao, Hu; Choung, Pill Hoon; Shi, Songtao; Chai, Yang.

In: STEM CELLS, Vol. 27, No. 4, 01.04.2009, p. 866-877.

Research output: Contribution to journalArticle

Chung, Il Hyuk ; Yamaza, Takayoshi ; Zhao, Hu ; Choung, Pill Hoon ; Shi, Songtao ; Chai, Yang. / Stem cell property of postmigratory cranial neural crest cells and their utility in alveolar bone regeneration and tooth development. In: STEM CELLS. 2009 ; Vol. 27, No. 4. pp. 866-877.
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